J
Josep M. Mercader
Researcher at Harvard University
Publications - 132
Citations - 8095
Josep M. Mercader is an academic researcher from Harvard University. The author has contributed to research in topics: Genome-wide association study & Type 2 diabetes. The author has an hindex of 34, co-authored 100 publications receiving 5957 citations. Previous affiliations of Josep M. Mercader include Polytechnic University of Catalonia & Massachusetts Institute of Technology.
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Journal ArticleDOI
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug
Hao Wu,Eduardo Esteve,Eduardo Esteve,Valentina Tremaroli,Muhammad Tanweer Khan,Robert Caesar,Louise Mannerås-Holm,Marcus Ståhlman,Lisa M. Olsson,Matteo Serino,Mercè Planas-Fèlix,Gemma Xifra,Gemma Xifra,Josep M. Mercader,David Torrents,David Torrents,Rémy Burcelin,Rémy Burcelin,Wifredo Ricart,Wifredo Ricart,Rosie Perkins,José Manuel Fernández-Real,José Manuel Fernández-Real,Fredrik Bäckhed,Fredrik Bäckhed,Fredrik Bäckhed +25 more
TL;DR: It is shown that metformin affected pathways with common biological functions in species from two different phyla, and many of the met formin-regulated genes in these species encoded metalloproteins or metal transporters, which provides support for the notion that altered gut microbiota mediates some of metformIn's antidiabetic effects.
Journal ArticleDOI
SNPassoc: an R package to perform whole genome association studies
Juan R. González,Lluís Armengol,Xavier Solé,Elisabet Guinó,Josep M. Mercader,Xavier Estivill,Victor Moreno +6 more
TL;DR: SNPassoc, an R package to carry out most common analyses in whole genome association studies, including descriptive statistics and exploratory analysis of missing values, calculation of Hardy-Weinberg equilibrium, analysis of association based on generalized linear models, and analysis of multiple SNPs.
Journal ArticleDOI
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations
Klaus Bønnelykke,Patrick M. A. Sleiman,Kasper Nielsen,Eskil Kreiner-Møller,Josep M. Mercader,Danielle Belgrave,Herman T. den Dekker,Anders Husby,Astrid Sevelsted,Grissel Faura-Tellez,Li Juel Mortensen,Lavinia Paternoster,Richard Flaaten,Anne Mølgaard,David E. Smart,Philip Francis Thomsen,Morten Arendt Rasmussen,Sílvia Bonàs-Guarch,Claus Holst,Ellen A. Nohr,Rachita Yadav,Michael E. March,Thomas Blicher,Peter M. Lackie,Vincent W. V. Jaddoe,Angela Simpson,John W. Holloway,Liesbeth Duijts,Adnan Custovic,Donna E. Davies,David Torrents,Ramneek Gupta,Mads V. Hollegaard,David M. Hougaard,Hakon Hakonarson,Hans Bisgaard +35 more
TL;DR: The results demonstrate the strength of applying specific phenotyping in the search for asthma susceptibility genes, and obtain strong evidence for a new susceptibility gene, CDHR3 (encoding cadherin-related family member 3), which is highly expressed in airway epithelium.
Journal ArticleDOI
Brain-derived neurotrophic factor Val66Met and psychiatric disorders: meta-analysis of case-control studies confirm association to substance-related disorders, eating disorders, and schizophrenia.
Mònica Gratacòs,Juan R. González,Josep M. Mercader,Rafael de Cid,Mikel Urretavizcaya,Xavier Estivill +5 more
TL;DR: The study confirms the association of Val66Met to substance-related disorders, eating disorders, and schizophrenia and investigates whether other variants in tight linkage disequilibrium with Val 66Met could configure an extended functional haplotype that would explain observed discrepancies in risk estimations across studies.
Journal ArticleDOI
Genome-wide associations for birth weight and correlations with adult disease
Momoko Horikoshi,Robin N Beaumont,Felix R. Day,Nicole M. Warrington,Nicole M. Warrington,Marjolein N. Kooijman,Juan Fernández-Tajes,Bjarke Feenstra,Natalie R. van Zuydam,Kyle J. Gaulton,Kyle J. Gaulton,Niels Grarup,Jonathan P. Bradfield,David P. Strachan,Ruifang Li-Gao,Tarunveer S. Ahluwalia,Tarunveer S. Ahluwalia,Eskil Kreiner,Rico Rueedi,Rico Rueedi,Leo-Pekka Lyytikäinen,Diana L. Cousminer,Diana L. Cousminer,Diana L. Cousminer,Ying Wu,Elisabeth Thiering,Carol A. Wang,Christian Theil Have,Jouke-Jan Hottenga,Natalia Vilor-Tejedor,Peter K. Joshi,Eileen Tai-Hui Boh,Ioanna Ntalla,Ioanna Ntalla,Niina Pitkänen,Anubha Mahajan,Elisabeth M. van Leeuwen,Raimo Joro,Vasiliki Lagou,Vasiliki Lagou,Michael Nodzenski,Louise A. Diver,Krina T. Zondervan,Mariona Bustamante,Pedro Marques-Vidal,Josep M. Mercader,Amanda J. Bennett,Nilufer Rahmioglu,Dale R. Nyholt,Ronald C.W. Ma,Claudia H. T. Tam,Wing Hung Tam,Santhi K. Ganesh,Frank J.A. van Rooij,Samuel E. Jones,Po-Ru Loh,Katherine S. Ruth,Marcus A. Tuke,Jessica Tyrrell,Andrew R. Wood,Hanieh Yaghootkar,Denise M. Scholtens,Lavinia Paternoster,Inga Prokopenko,Inga Prokopenko,Peter Kovacs,Mustafa Atalay,Sara M. Willems,Kalliope Panoutsopoulou,Xu Wang,Lisbeth Carstensen,Frank Geller,Katharina E. Schraut,Mario Murcia,Catharina E. M. van Beijsterveldt,Gonneke Willemsen,Emil V. R. Appel,Cilius Esmann Fonvig,Cæcilie Trier,Carla M. T. Tiesler,Marie Standl,Zoltán Kutalik,Zoltán Kutalik,Sílvia Bonàs-Guarch,David M. Hougaard,Friman Sánchez,David Torrents,Johannes Waage,Mads V. Hollegaard,Hugoline G. de Haan,Frits R. Rosendaal,Carolina Medina-Gomez,Susan M. Ring,Gibran Hemani,George McMahon,Neil R. Robertson,Christopher J. Groves,Claudia Langenberg,Jian'an Luan,Robert A. Scott,Jing Hua Zhao,Frank D. Mentch,Scott M. MacKenzie,Rebecca M. Reynolds,William L. Lowe,Anke Tönjes,Michael Stumvoll,Virpi Lindi,Timo A. Lakka,Cornelia M. van Duijn,Wieland Kiess,Antje Körner,Thorkild I. A. Sørensen,Harri Niinikoski,Katja Pahkala,Olli T. Raitakari,Eleftheria Zeggini,George Dedoussis,Yik Ying Teo,Seang-Mei Saw,Mads Melbye,Mads Melbye,Mads Melbye,Harry Campbell,James F. Wilson,Martine Vrijheid,Eco J. C. de Geus,Eco J. C. de Geus,Dorret I. Boomsma,Haja N. Kadarmideen,Jens-Christian Holm,Torben Hansen,Sylvain Sebert,Sylvain Sebert,Andrew T. Hattersley,Lawrence J. Beilin,John P. Newnham,Craig E. Pennell,Joachim Heinrich,Linda S. Adair,Judith B. Borja,Karen L. Mohlke,Johan G. Eriksson,Johan G. Eriksson,Elisabeth Widen,Mika Kähönen,Jorma Viikari,Terho Lehtimäki,Peter Vollenweider,Klaus Bønnelykke,Hans Bisgaard,Dennis O. Mook-Kanamori,Albert Hofman,Fernando Rivadeneira,André G. Uitterlinden,Charlotta Pisinger,Oluf Pedersen,Christine Power,Elina Hyppönen,Elina Hyppönen,Nicholas J. Wareham,Hakon Hakonarson,Eleanor Davies,Brian R. Walker,Vincent W. V. Jaddoe,Marjo-Riitta Järvelin,Struan F.A. Grant,Allan Vaag,Allan Vaag,Debbie A Lawlor,Timothy M. Frayling,George Davey Smith,Andrew P. Morris,Andrew P. Morris,Andrew P. Morris,Ken K. Ong,Janine F. Felix,Nicholas J. Timpson,John R. B. Perry,David M. Evans,David M. Evans,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Rachel M. Freathy,Rachel M. Freathy +185 more
TL;DR: In this paper, the authors performed a meta-analysis of birth weight in 153,781 individuals, identifying 60 loci where fetal genotype was associated with birth weight (P < 5.5×10−8).