Peter Ouillette

TL;DR: The genomic profile of tFL shares similarities with that of germinal center B cell-type de novo DLBCL but also displays unique combinations of altered genes with diagnostic and therapeutic implications.

TL;DR: In this article, a recently developed inhibitor MM-401 that targets the MLL1 H3K4 methyltransferase activity is presented, which is able to specifically inhibit MLL 1 activity by blocking MLL-WDR5 interaction and thus the complex assembly.

TL;DR: Results show that inhibiting MLL1 methyltransferase activity specifically blocks proliferation of MLL cells by inducing cell-cycle arrest, apoptosis, and myeloid differentiation without general toxicity to normal bone marrow cells or non-MLL cells.

TL;DR: High-resolution genomic maps and array-based measurements of expression levels of RNA in CLL cases with and without del13q14 and quantitative PCR-based expression analysis of selected genes support the following conclusions: (a) del 13q14 is heterogeneous and composed of multiple subtypes, with deletion of Rb or the miR15a/miR16 loci serving as anatomic landmarks, respectively.

TL;DR: The results of massively parallel exome sequencing and single nucleotide polymorphism 6.0 array genomic profiling of 11 highly purified FL cases, and 1 transformed FL case and the validation of selected mutations in 102 FL cases substantially broaden the understanding of the genomic pathogenesis of FL.