M
Marcus Perola
Researcher at National Institutes of Health
Publications - 3
Citations - 547
Marcus Perola is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Genome-wide association study & Single-nucleotide polymorphism. The author has an hindex of 2, co-authored 3 publications receiving 543 citations.
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Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations
Melanie Kolz,Toby Johnson,Serena Sanna,Alexander Teumer,Veronique Vitart,Marcus Perola,Massimo Mangino,Eva Albrecht,Chris Wallace,Martin Farrall,Åsa Johansson,Dale R. Nyholt,Yurii S. Aulchenko,Jacques S. Beckmann,Sven Bergmann,Murielle Bochud,Matthew A. Brown,Harry Campbell,John M. C. Connell,Anna F. Dominiczak,Georg Homuth,Claudia Lamina,Mark I. McCarthy,Thomas Meitinger,Vincent Mooser,Patricia B. Munroe,Matthias Nauck,John F. Peden,Holger Prokisch,Perttu Salo,Veikko Salomaa,Nilesh J. Samani,David Schlessinger,Manuela Uda,Uwe Völker,Gérard Waeber,Dawn M. Waterworth,Rui Wang-Sattler,Alan F. Wright,Jerzy Adamski,John Whitfield,Ulf Gyllensten,James F. Wilson,Igor Rudan,Peter P. Pramstaller,Hugh Watkins,Angela Doering,Heinz Erich Wichmann,Kora Study,Tim D. Spector,Leena Peltonen,Henry Völzke,Ramaiah Nagaraja,Peter Vollenweider,Mark J. Caulfield,Thomas Illig,Christian Gieger +56 more
TL;DR: The hypothesis that transport proteins are key in regulating serum uric acid levels is supported, as 954 SNPs distributed across nine loci that exceeded the threshold of genome-wide significance were identified, five of which are novel.
Genome-wide meta-analysis of common variant differences between men and women
Vesna Boraska,Ana Jerončić,Vincenza Colonna,Lorraine Southam,Dale R. Nyholt,N W Rayner,John R. B. Perry,Daniela Toniolo,Eva Albrecht,Wei Ang,Stefania Bandinelli,Maja Barbalić,Inês Barroso,Jacques S. Beckmann,Reiner Biffar,Dorret I. Boomsma,Harry Campbell,Tanguy Corre,Jeanette Erdmann,Tõnu Esko,Krista Fischer,Nora Franceschini,Timothy M. Frayling,Giorgia Girotto,Juan R. González,Tamara B. Harris,A. C. Heath,I. M. Heid,W. Hoffmann,Albert Hofman,Momoko Horikoshi,Jing Hua Zhao,Anne U. Jackson,Jouke-Jan Hottenga,A. Jula,Mika Kähönen,Kay-Tee Khaw,Lambertus A. Kiemeney,N Klopp,Zoltán Kutalik,Vasiliki Lagou,Lenore J. Launer,Terho Lehtimäki,Mathieu Lemire,M. L. Lokki,Christina Loley,Jian'an Luan,Massimo Mangino,I. Mateo Leach,S. E. Medland,Evelin Mihailov,Grant W. Montgomery,Gerjan Navis,John P. Newnham,Nieminen,Aarno Palotie,Kalliope Panoutsopoulou,Annette Peters,Nicola Pirastu,Ozren Polasek,Karola Rehnström,Samuli Ripatti,Graham R S Ritchie,Fernando Rivadeneira,Antonietta Robino,Nilesh J. Samani,So-Youn Shin,Juha Sinisalo,J.H. Smit,Nicole Soranzo,Lisette Stolk,Dorine W. Swinkels,Toshiko Tanaka,Alexander Teumer,A Tönjes,Michela Traglia,Jaakko Tuomilehto,Armand Valsesia,W. H. Van Gilst,J.B. van Meurs,Albert V. Smith,Jorma Viikari,J.M. Vink,G. Waeber,Nicole M. Warrington,E. Widen,Gonneke Willemsen,A. F. Wright,Brent W. Zanke,Lina Zgaga,Michael Boehnke,Adamo Pio d'Adamo,E.J.C. de Geus,W. Demerath,M. den Heijer,Johan G. Eriksson,Luigi Ferrucci,Christian Gieger,Vilmundur Gudnason,Caroline Hayward,Christian Hengstenberg,Thomas J. Hudson,Marjo-Riitta Järvelin,Manolis Kogevinas,Ruth J. F. Loos,Nicholas G. Martin,Andres Metspalu,Craig E. Pennell,B.W.J.H. Penninx,Marcus Perola,Olli T. Raitakari,Veikko Salomaa,Stefan Schreiber,Heribert Schunkert,Tim D. Spector,Michael Stumvoll,André G. Uitterlinden,S. Ulivi,P. van der Harst,Peter Vollenweider,Henry Völzke,Nicholas J. Wareham,H. E. Wichmann,James F. Wilson,Igor Rudan,Yali Xue,Eleftheria Zeggini +126 more
TL;DR: This paper conducted a large-scale genome-wide association scan (GWAS) meta-analysis across 51 studies, comprising overall 114 863 individuals (61 094 women and 53 769 men) of European ancestry and 2 623 828 common (minor allele frequency > 0.05) single-nucleotide polymorphisms (SNPs).
Journal ArticleDOI
Multivariate genome-wide analysis of immunoglobulin G N-glycosylation identifies new loci pleiotropic with immune function.
Alexandra S. Shadrina,Alexander S. Zlobin,Olga O. Zaytseva,Lucija Klaric,Sodbo Zh Sharapov,Eugene D Pakhomov,Marcus Perola,Tõnu Esko,Caroline Hayward,James F. Wilson,Gordan Lauc,Yurii S. Aulchenko,Yakov A. Tsepilov +12 more
TL;DR: In this article, the authors conducted a multivariate genome-wide association analysis of 23 IgG N-glycosylation traits measured in 8090 individuals of European ancestry and found that two of these loci were previously implicated in rare immune deficiencies and were associated with levels of circulating immunoglobulins.