M
Marcy E. MacDonald
Researcher at Harvard University
Publications - 322
Citations - 52277
Marcy E. MacDonald is an academic researcher from Harvard University. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 96, co-authored 315 publications receiving 49085 citations. Previous affiliations of Marcy E. MacDonald include Huntington's Disease Society of America & Ontario Institute for Cancer Research.
Papers
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Journal ArticleDOI
Prevalence of Huntington's disease gene CAG trinucleotide repeat alleles in patients with bipolar disorder
Eliana Marisa Ramos,Eliana Marisa Ramos,Tammy Gillis,Jayalakshmi S. Mysore,Jong-Min Lee,Isabel Alonso,James F. Gusella,Jordan W. Smoller,Pamela Sklar,Marcy E. MacDonald,Roy H. Perlis +10 more
TL;DR: A greater than expected prevalence of incompletely penetrant HTT CAG repeat alleles observed among individuals diagnosed with major depressive disorder raises the possibility that another mood disorder, bipolar disorder, could likewise be associated with Huntington's disease.
Journal ArticleDOI
Expanding the notion of disease in Huntington's disease.
TL;DR: Although the subtle sychiatric differences cannot themselves be considered diagostic of HD, they do reveal that the HD mutation makes a ifference before the appearance of those symptoms that are iagnostic, to reinforce the notion that there are differnces between HD mutation carriers and non-HD mutation.
Patent
Transgenic nematode model of triplet repeat neurological diseases
TL;DR: In this article, transgenic nematodes were used to provide model systems for Triplet Repeat Neurological Diseases (TRENDS), which is a type of neuropathological disorders with multiple symptoms.
Journal ArticleDOI
Chromosome substitution strain assessment of a Huntington's disease modifier locus.
Eliana Marisa Ramos,Eliana Marisa Ramos,Marina Kovalenko,Jolene R. Guide,Jason St. Claire,Tammy Gillis,Jayalakshmi S. Mysore,Jorge Sequeiros,Vanessa C. Wheeler,Isabel Alonso,Marcy E. MacDonald +10 more
TL;DR: A novel human–mouse cross-species functional prioritisation approach is explored, by evaluating the HD modifier 6q23–24 linkage interval, suggestive of dominant chr10 AJ-B6 variants that may modify effects of the CAG expansion, and encourage a larger study with CSS10 and sub-strains.
Journal ArticleDOI
Assignment of the human gene encoding eukaryotic initiation factor 4E (EIF4E) to the region q21-25 on chromosome 4.
Robin M. Jones,Marcy E. MacDonald,John A. Branda,Michael R. Altherr,David N. Louis,Emmett V. Schmidt +5 more
TL;DR: Using oligonucleotide primers specific for the promoter region in polymerase chain reactions (PCR), the eIF4E gene was amplified in a chromosome 4-specific human/rodent somatic cell panel and single copy genomic sequences were mapped.