M
Marcy E. MacDonald
Researcher at Harvard University
Publications - 322
Citations - 52277
Marcy E. MacDonald is an academic researcher from Harvard University. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 96, co-authored 315 publications receiving 49085 citations. Previous affiliations of Marcy E. MacDonald include Huntington's Disease Society of America & Ontario Institute for Cancer Research.
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Journal ArticleDOI
The Genetic Defect Causing Huntington’s Disease: Repeated in Other Contexts?
TL;DR: The clinical progression of HD is paralleled by neuronal degeneration in the brain and the proximate cause of the neuronal dysfunction and death is not yet known, it is ultimately due to the presence of a mutant gene.
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A somatic cell hybrid panel for localizing DNA segments near the Huntington's disease gene.
Marcy E. MacDonald,Mary Anne Anderson,T. Conrad Gilliam,Lisbeth Tranebjaerg,Nancy J. Carpenter,Ellen Magenis,Michael R. Hayden,Steven T. Healey,Tom I. Bonner,James F. Gusella +9 more
TL;DR: A panel of somatic cell hybrid lines provides a rapid method for mapping new probes to the same vicinity as that of D4S10, and the relative paucity of such DNA segments identified here suggests that a more directed approach may be required to generate additional markers near the HD gene.
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Risk factors for hepatitis C virus infection among injecting drug users in Sydney.
TL;DR: Recent HCV transmission indicates ongoing injecting risk behaviour despite HIV prevention efforts, and underlies the potential for increased transmission of HIV through the sharing of injecting equipment.
Journal Article
A yeast artificial chromosome telomere clone spanning a possible location of the Huntington disease gene.
Gillian P. Bates,Marcy E. MacDonald,Sarah Baxendale,Zdenek Sedlacek,S. Youngman,Donna M. Romano,W L Whaley,Bernice A. Allitto,Annemarie Poustka,J. F. Gusella,Hans Lehrach +10 more
TL;DR: A yeast artificial chromosome vector is constructed for the cloning of mammalian telomeres, used to prepare a BssHII-telomere library with DNA from an individual homozygous for HD, and a 115-kb clone containing the telomere of 4p is identified.
Journal ArticleDOI
Transcriptional regulatory networks underlying gene expression changes in Huntington's disease
Seth A. Ament,Seth A. Ament,Jocelynn R. Pearl,Jocelynn R. Pearl,Jeffrey P. Cantle,Robert M. Bragg,Peter J Skene,Sydney R. Coffey,Dani E Bergey,Vanessa C. Wheeler,Marcy E. MacDonald,Nitin S. Baliga,Jim Rosinski,Leroy Hood,Jeffrey B. Carroll,Nathan D. Price +15 more
TL;DR: A specific model prediction that SMAD3 regulates HD‐related gene expression changes is experimentally validated using chromatin immunoprecipitation and deep sequencing of mouse striatum and CAG repeat length‐dependent changes in the genomic occupancy ofSMAD3 are found.