M
Marcy E. MacDonald
Researcher at Harvard University
Publications - 322
Citations - 52277
Marcy E. MacDonald is an academic researcher from Harvard University. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 96, co-authored 315 publications receiving 49085 citations. Previous affiliations of Marcy E. MacDonald include Huntington's Disease Society of America & Ontario Institute for Cancer Research.
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Book ChapterDOI
Huntington’s Disease
TL;DR: The genetic homogeneity of HD offers the opportunity to investigate the disease process from early in life and to devise treatments that are effective long before onset of disease symptoms.
Posted ContentDOI
Modulation of huntingtin degradation by cAMP-dependent protein kinase A (PKA) phosphorylation of C-HEAT domain Ser2550
Ye-Jin Lee,Hyeongju Kim,Douglas Barker,Ravi Vijayvargia,Ranjit Singh Atwal,Harrison Specht,Hasmik Keshishian,Steven A. Carr,Ramee Lee,Seung Kwak,Kyung-gi Hyun,Jacob M. Loupe,Marcy E. MacDonald,Ji-Joon Song,Ihn Sik Seong +14 more
TL;DR: Mass spectrometry-based phosphoproteomics is employed to systematically identify sites in purified huntingtin and in the endogenous protein, by proteomic and phospho-proteomic analyses of members of an HD neuronal progenitor cell panel, and phosphorylation of C-HEAT Ser2550 by cAMP-dependent protein kinase was found to hasten huntingtin degradation.