M
Marcy E. MacDonald
Researcher at Harvard University
Publications - 322
Citations - 52277
Marcy E. MacDonald is an academic researcher from Harvard University. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 96, co-authored 315 publications receiving 49085 citations. Previous affiliations of Marcy E. MacDonald include Huntington's Disease Society of America & Ontario Institute for Cancer Research.
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Journal Article
A recombination event that redefines the Huntington disease region
Russell G. Snell,Leslie M. Thompson,Danilo A. Tagle,T L Holloway,Glenn Barnes,H G Harley,L A Sandkuijl,Marcy E. MacDonald,Frank H. Collins,J. F. Gusella +9 more
TL;DR: A recombination event is reported that places the Huntington disease gene proximal to the marker D4S98 and an extended linkage-disequilibrium study that uses this marker and confirms the existence of disequilibrium between it and the HD locus.
Journal ArticleDOI
Huntington's Disease and Repeating Trinucleotides
TL;DR: A person with Huntington's disease at midlife onset is likely to have a history of depression, especially around the period of transition from hunter-gatherers to non-huntington's disease patients.
Journal ArticleDOI
TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington’s disease
Ji Hyun Lee,Jong-Min Lee,Eliana Marisa Ramos,Tammy Gillis,Jayalakshmi S. Mysore,Shotaro Kishikawa,Tiffany C. Hadzi,Audrey E. Hendricks,Michael R. Hayden,Patrick J. Morrison,Martha Nance,Christopher A. Ross,Russell L. Margolis,Ferdinando Squitieri,Cinzia Gellera,Estrella Gómez-Tortosa,Carmen Ayuso,Oksana Suchowersky,Ronald J. Trent,Elizabeth McCusker,Andrea Novelletto,Marina Frontali,Randi Jones,Tetsuo Ashizawa,Samuel Frank,Marie Saint-Hilaire,Steven M. Hersch,H. D. Rosas,Diane Lucente,Madaline B. Harrison,Andrea Zanko,Ruth K. Abramson,Karen Marder,Jorge Sequeiros,G. Bernhard Landwehrmeyer,Ira Shoulson,Richard H. Myers,Marcy E. MacDonald,James F. Gusella +38 more
TL;DR: Comprehensive analytical methods applied to a much larger sample than in previous studies do not support a role for GRIK2 as a genetic modifier of age at onset of clinical symptoms in Huntington's disease.
Journal ArticleDOI
A DNA probe, D5 [D4S90] mapping to human chromosome 4p16.3.
S. Youngman,D.J. Shaw,James F. Gusella,Marcy E. MacDonald,Eric J. Stanbridge,John J. Wasmuth,Peter S. Harper +6 more
Journal ArticleDOI
Haplotype-based stratification of Huntington's disease.
Michael J. Chao,Tammy Gillis,Ranjit Singh Atwal,Jayalakshmi S. Mysore,Jamshid Arjomand,Denise Harold,Peter Holmans,Lesley Jones,Michael Orth,Richard H. Myers,Seung Kwak,Vanessa C. Wheeler,Marcy E. MacDonald,Marcy E. MacDonald,James F. Gusella,James F. Gusella,Jong-Min Lee,Jong-Min Lee +17 more
TL;DR: The haplotypes present in a series of publicly available HD subject-derived fibroblasts, induced pluripotent cells, and embryonic stem cells are determined in order to facilitate efforts to develop inclusive methods of allele-specific HTT silencing applicable to most HD patients.