M
Marcy E. MacDonald
Researcher at Harvard University
Publications - 322
Citations - 52277
Marcy E. MacDonald is an academic researcher from Harvard University. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 96, co-authored 315 publications receiving 49085 citations. Previous affiliations of Marcy E. MacDonald include Huntington's Disease Society of America & Ontario Institute for Cancer Research.
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Journal ArticleDOI
Inactivation of the Huntington's disease gene (Hdh) impairs anterior streak formation and early patterning of the mouse embryo
Juliana M. Woda,Teresa Calzonetti,Paige Hilditch-Maguire,Mabel P. Duyao,Ronald A. Conlon,Marcy E. MacDonald +5 more
TL;DR: Huntingtin is essential in the early patterning of the embryo for formation of the anterior region of the primitive streak, and for down-regulation of a subset of dynamic growth and transcription factor genes.
Journal ArticleDOI
Prevalence of Incompletely Penetrant Huntington's Disease Alleles Among Individuals With Major Depressive Disorder
Roy H. Perlis,Jordan W. Smoller,Jayalakshmi S. Mysore,Mei Sun,Tammy Gillis,Shaun Purcell,Marcella Rietschel,Markus M. Nöthen,Stephanie H. Witt,Wolfgang Maier,Dan V. Iosifescu,Patrick F. Sullivan,A. John Rush,Maurizio Fava,Hans C. Breiter,Marcy E. MacDonald,James F. Gusella +16 more
TL;DR: Presymptomatic individuals with the Huntingtin (HTT) CAG expansion mutation that causes Huntington's disease may have higher levels of depressive symptoms than healthy comparison populations.
Journal ArticleDOI
Metabolic disruption identified in the Huntington’s disease transgenic sheep model
Renee R. Handley,Suzanne J. Reid,Stefano Patassini,Skye R. Rudiger,Vladimir Obolonkin,Clive J. McLaughlan,Jessie C. Jacobsen,James F. Gusella,Marcy E. MacDonald,Henry J. Waldvogel,C. Simon Bawden,Richard L.M. Faull,Russell G. Snell +12 more
TL;DR: Differences in metabolite abundance indicate a metabolic disruption in the sheep model of HD and could provide insight into the presymptomatic human disease.
Journal ArticleDOI
An over-expression system for characterizing Ppt1 function in Drosophila.
TL;DR: It is reported that over-expression of DmPpt1 in the developing Drosophila visual system leads to the loss of cells through apoptotic cell death, suggesting that the precise levels of PPT1 activity are important for neuronal cell survival.
Journal ArticleDOI
Meclizine is neuroprotective in models of Huntington's disease
Vishal M. Gohil,Nicolas Offner,Nicolas Offner,James A. Walker,Sunil A Sheth,Sunil A Sheth,Elisa Fossale,James F. Gusella,James F. Gusella,Marcy E. MacDonald,Marcy E. MacDonald,Christian Neri,Christian Neri,Vamsi K. Mootha,Vamsi K. Mootha +14 more
TL;DR: It is shown that meclizine, a clinically used drug that has recently been shown to silence oxidative metabolism, suppresses apoptotic cell death in a murine cellular model of polyglutamine (polyQ) toxicity, and this protective effect extends to neuronal dystrophy and cellDeath in Caenorhabditis elegans and Drosophila melanogaster models of polyQ toxicity.