M
Marcy E. MacDonald
Researcher at Harvard University
Publications - 322
Citations - 52277
Marcy E. MacDonald is an academic researcher from Harvard University. The author has contributed to research in topics: Huntington's disease & Huntingtin. The author has an hindex of 96, co-authored 315 publications receiving 49085 citations. Previous affiliations of Marcy E. MacDonald include Huntington's Disease Society of America & Ontario Institute for Cancer Research.
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Journal ArticleDOI
A new DNA marker (D4S90) is located terminally on the short arm of chromosome 4, close to the Huntington disease gene.
S. Youngman,Mansoor Sarfarazi,Maja Bucan,Marcy E. MacDonald,Barbara Smith,Michael Zimmer,Conrad Gilliam,Anna-Maria Frischauf,John J. Wasmuth,James F. Gusella,Hans Lehrach,Peter S. Harper,D.J. Shaw +12 more
TL;DR: A new DNA marker, D4S90 (D5); which maps to the distal region of 4p16.3, is described, which should play an important role in the accurate mapping and cloning of the HD gene.
Journal ArticleDOI
A gene from chromosome 4p16.3 with similarity to a superfamily of transporter proteins
Mabel P. Duyao,Sherryl A.M. Taylor,Alan Buckler,Christine Ambrose,Carol Lin,Nicolet Groot,Deanna Church,Glenn Barnes,John J. Wasmuth,David E. Housman,Marcy E. MacDonald,James F. Gusella +11 more
TL;DR: Using exon amplification to identify the ADD1 gene in cosmid Y24 from the Huntington's disease (HD) region of 4p16.3 should open a route to isolating additional mammalian members of this growing superfamily of transporter proteins.
Journal ArticleDOI
Erythrocyte membrane antigen expression during Friend cell differentiation: analysis of two non-inducible variants.
Marcy E. MacDonald,Marcy E. MacDonald,Michelle Letarte,Michelle Letarte,Alan Bernstein,Alan Bernstein +5 more
TL;DR: Reciprocal inhibition studies demonstrated that, following complete thymocyte absorption, the antiserum detected similar antigenic specificities, termed erythrocyte membrane antigens (EMA), on both mature ery Throcytes and induced Friend cells.
Journal ArticleDOI
Huntington disease-linked locus D4S111 exposed as the alpha-L-iduronidase gene.
Marcy E. MacDonald,Hamish S. Scott,W L Whaley,Pohl T,John J. Wasmuth,Hans Lehrach,Charles P. Morris,A.-M. Frischauf,John J. Hopwood,James F. Gusella +9 more
TL;DR: In this article, the location of the alpha-L-iduronidase (IDUA) gene was localized to 4p16.3, the region of chromosome 4 associated with Huntington's disease (HD).
Journal ArticleDOI
Isolation of a novel mildly repetitive DNA sequence that is predominantly located at the terminus of the short arm of chromosome 4 near the Huntington disease gene.
TL;DR: A cloned probe that detects the repeated sequence reveals a restriction fragment length polymorphism that is close to and/or distal to the most distal genetic locus on 4p, which provides a new genetic marker very close and possibly flanking the HD gene.