D
Douglas Barker
Researcher at Harvard University
Publications - 33
Citations - 3378
Douglas Barker is an academic researcher from Harvard University. The author has contributed to research in topics: Gene & Gene expression. The author has an hindex of 18, co-authored 32 publications receiving 2947 citations. Previous affiliations of Douglas Barker include Broad Institute & University of California, Los Angeles.
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Journal ArticleDOI
De novo mutations in schizophrenia implicate synaptic networks
Menachem Fromer,Andrew Pocklington,David J. Kavanagh,Hywel Williams,Sarah Dwyer,Padhraig Gormley,Lyudmila Georgieva,Elliott Rees,Priit Palta,Douglas M. Ruderfer,Noa Carrera,Isla Humphreys,Jessica S. Johnson,Panos Roussos,Douglas Barker,Eric Banks,Vihra Milanova,Seth G. N. Grant,Eilis Hannon,Samuel A. Rose,Kimberly Chambert,Milind Mahajan,Edward M. Scolnick,Jennifer L. Moran,George Kirov,Aarno Palotie,Steven A. McCarroll,Peter Holmans,Pamela Sklar,Michael John Owen,Shaun Purcell,Michael Conlon O'Donovan +31 more
TL;DR: Genes affected by mutations in schizophrenia overlap those mutated in autism and intellectual disability, as do mutation-enriched synaptic pathways, and pathophysiology shared with other neurodevelopmental disorders.
Journal ArticleDOI
Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection.
Douglas Barker,Arnold J. Berk +1 more
TL;DR: Studies with a third mutant virus, pm2022, suggest that very low levels of 495R protein activity are sufficient for a productive infection and significant transforming activity, and provide evidence that the observed transformation defect is not due to the death of transformed cells.
Journal ArticleDOI
CAG repeat not polyglutamine length determines timing of Huntington’s disease onset
Jongmin Lee,Kevin Correia,Jacob M. Loupe,Kyung Hee Kim,Douglas Barker,Eun Pyo Hong,Michael J. Chao,Jeffrey D. Long,Diane Lucente,Jean Paul G. Vonsattel,Ricardo Mouro Pinto,Kawther Abu Elneel,Eliana Marisa Ramos,Jayalakshmi S. Mysore,Tammy Gillis,Vanessa C. Wheeler,Marcy E. MacDonald,James F. Gusella,Branduff McAllister,Thomas Massey,Christopher Medway,Timothy Stone,Lynsey S. Hall,Lesley Jones,Peter Holmans,Seung Kwak,Anka G. Ehrhardt,Cristina Sampaio,Marc Ciosi,Alastair Maxwell,Afroditi Chatzi,Darren G. Monckton,Michael Orth,G. Bernhard Landwehrmeyer,Jane S. Paulsen,E. Ray Dorsey,Ira Shoulson,Richard H. Myers +37 more
TL;DR: Variable, glutamine-encoding, CAA interruptions indicate that a property of the uninterrupted HTT CAG repeat sequence, distinct from the length of huntingtin’s polyglutamine segment, dictates the rate at which Huntington's disease (HD) develops.
Journal ArticleDOI
Pumilio is essential for function but not for distribution of the Drosophila abdominal determinant nanos
TL;DR: It is shown that the expression and distribution of nanos RNA and protein in embryos derived from pumilio mutant females are indistinguishable from wild type, and it is concluded that abdomen formation depends both on Nanos activity, spreading from the localized posterior source, and on Pumilios activity, present throughout the embryo.
Journal ArticleDOI
Characterization of Bipolar Disorder Patient-Specific Induced Pluripotent Stem Cells from a Family Reveals Neurodevelopmental and mRNA Expression Abnormalities
Jon M. Madison,Jon M. Madison,Fen Zhou,Fen Zhou,A Nigam,A Nigam,A Hussain,A Hussain,Douglas Barker,Ralda Nehme,Ralda Nehme,K van der Ven,Joey Hsu,Joey Hsu,Philip A. Wolf,Philip A. Wolf,M Fleishman,M Fleishman,Colm O'Dushlaine,Samuel A. Rose,Kimberly Chambert,Frank H. Lau,Frank H. Lau,Tim Ahfeldt,E H Rueckert,E H Rueckert,Steven D. Sheridan,Daniel M. Fass,Daniel M. Fass,James Nemesh,James Nemesh,Thomas E. Mullen,Thomas E. Mullen,Laurence Daheron,Steven A. McCarroll,Steven A. McCarroll,Pamela Sklar,Roy H. Perlis,Stephen J. Haggarty +38 more
TL;DR: These studies provide new cellular tools for dissecting the pathophysiology of BD and evidence for dysregulation of key pathways involved in neurodevelopment and neuroplasticity.