M
Maria Carna
Publications - 3
Citations - 149
Maria Carna is an academic researcher. The author has contributed to research in topics: Neurite & Pyroptosis. The author has an hindex of 2, co-authored 3 publications receiving 59 citations.
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Journal ArticleDOI
Neuroinflammation in Alzheimer's Disease.
TL;DR: In this paper, the authors discuss some current ideas on processes in inflammaging that appear to drive the neurodegenerative process in Alzheimer's disease and summarize details on a few immunomodulatory strategies being developed to selectively target the detrimental aspects of neuroinflammation without affecting defense mechanisms against pathogens and tissue damage.
Journal ArticleDOI
Tau Isoforms Imbalance Impairs the Axonal Transport of the Amyloid Precursor Protein in Human Neurons.
Valentina Lacovich,Sonia Espindola,Matías Alloatti,Victorio Martin Pozo Devoto,Lucas Eneas Cromberg,Maria Carna,Giancarlo Forte,Jean-Marc Gallo,Luciana Bruno,Gorazd B. Stokin,M. Elena Avale,Tomás L. Falzone,Tomás L. Falzone +12 more
TL;DR: It is found that perturbations in the endogenous balance of tau isoforms were sufficient to impair the transport of the Alzheimer's disease-related amyloid precursor protein (APP), although neuronal morphology was normal, and changes in 3R:4R tau ratio has an impact on the regulation of axonal transport and specifically in APP dynamics.
Posted ContentDOI
Failure of the choroid plexus in Alzheimer's disease
Maria Carna,Isaac G. Onyango,Stanislav Katina,Dusan Holub,Marketa Nezvedova,Durga Jha,Zuzana Nedelska,Valentina Lacovich,Thijs Vande Vyvere,Ruben Houbrechts,Krystine Garcia-Mansfield,Ritin Sharma,Victoria David-Dirgo,Martin Vyhnalek,Kateřina Texlova,Hernan Chaves,Nadine Bakkar,Lucia Pertierra,Mojmir Vinkler,Hana Markova,Jan Laczó,Kateřina Sheardová,Jan Fric,Giancarlo Forte,Petr Kaňovsky,Silvie Belaskova,Jiri Damborsky,Jakub Hort,Nicholas T. Seyfried,Robert Bowser,Gustavo Sevlever,Robert A. Rissman,Richard A. G. Smith,Marian Hajduch,Patrick Pirrotte,Patrick Pirrotte,Zdenek Spacil,Eric B. Dammer,Clara Limbäck-Stokin,Clara Limbäck-Stokin,Gorazd B. Stokin +40 more
TL;DR: In this article, the choroid plexus in Alzheimer's disease exhibits a pro-inflammatory signature with aberrant protein accumulations, which contribute to the age-dependent inflammatory changes observed in the cerebrospinal fluid.