Maria Giovanna Chini

TL;DR: GP-BAR1 regulates intestinal barrier structure and expression increases in rodent models of colitis and Crohn's disease and ciprofloxacin is a GP-Bar1 ligand.

TL;DR: The SAVE-MORE trial as discussed by the authors evaluated the efficacy and safety of anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at risk of progressing to respiratory failure.

TL;DR: This work used in silico screening to rapidly direct the synthesis of 15 compounds that at least in theory were shown to be more efficient in inhibiting mPGES-1, and designed 26 new triazole-based compounds in accordance with the pocket binding requirements of human mPGes-1.

TL;DR: It is concluded that TIIA and CRY display anti‐inflammatory and neuroprotective effect in a non‐genetic mouse model of AD, thus playing a role in slowing down the course and onset of AD.

TL;DR: In this paper, the authors highlight the recent goals reached by the application of a combined approach of NMR spectroscopy and quantum chemical methods in the structural studies of natural products, showing the comparison of calculated NMR parameters at the quantum mechanical (QM) theory level with experimental data for the configurational assignment of organic compounds.