M
Maria Markaki
Researcher at Foundation for Research & Technology – Hellas
Publications - 41
Citations - 7502
Maria Markaki is an academic researcher from Foundation for Research & Technology – Hellas. The author has contributed to research in topics: Autophagy & Mitophagy. The author has an hindex of 20, co-authored 35 publications receiving 6106 citations. Previous affiliations of Maria Markaki include University of Crete.
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Journal ArticleDOI
3,4-Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB.
Guo Chen,Wei Xie,Jihoon Nah,Allan Sauvat,Peng Liu,Federico Pietrocola,Valentina Sica,Didac Carmona-Gutierrez,Andreas Zimmermann,Tobias Pendl,Jelena Tadic,Martina Bergmann,Sebastian J. Hofer,Lana Domuz,Lana Domuz,Sylvie Lachkar,Maria Markaki,Nektarios Tavernarakis,Nektarios Tavernarakis,Junichi Sadoshima,Frank Madeo,Oliver Kepp,Guido Kroemer +22 more
TL;DR: The results suggest that 3,4‐DC is a novel CRM with a previously unrecognized mode of action, which induced autophagy in vitro and in mouse organs, mediated Autophagy‐dependent cardioprotective effects, and improved the efficacy of anticancer chemotherapy in vivo.
Book ChapterDOI
Novel Insights Into the Anti-aging Role of Mitophagy
TL;DR: The molecular signaling pathways that regulate and coordinate mitophagy with mitochondrial biogenesis are reviewed, highlighting critical factors that hold promise for the development of pharmacological interventions toward enhancing human health and quality of life throughout aging.
Journal ArticleDOI
Metabolic Control by Target of Rapamycin and Autophagy during Ageing - A Mini-Review
TL;DR: Recent developments that outline how TOR and autophagy modulate the ageing process are summarized, with special emphasis on their role in the regulation of metabolism.
Journal ArticleDOI
A Validated Clinical Risk Prediction Model for Lung Cancer in Smokers of All Ages and Exposure Types: A HUNT Study.
Maria Markaki,Ioannis Tsamardinos,Arnulf Langhammer,Vincenzo Lagani,Kristian Hveem,Oluf Dimitri Røe,Oluf Dimitri Røe,Oluf Dimitri Røe +7 more
TL;DR: A validated risk assessment model for lung cancer screening that includes age, pack-years, smoking intensity, years since smoking cessation, body mass index, daily cough, and hours of daily indoors exposure to smoke is presented.
Journal ArticleDOI
Maintenance of Proteostasis by P Body-Mediated Regulation of eIF4E Availability during Aging in Caenorhabditis elegans.
Matthias Rieckher,Maria Markaki,Andrea Princz,Björn Schumacher,Nektarios Tavernarakis,Nektarios Tavernarakis +5 more
TL;DR: It is shown that the eIF4E isoform IFE-2 is increasingly sequestered in mRNA processing (P) bodies during aging and upon stress in Caenorhabditis elegans, elucidate a mechanism of proteostasis control during aging through P body-mediated regulation of protein synthesis in the soma.