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Andreas Zimmermann
Researcher at University of Graz
Publications - 30
Citations - 2171
Andreas Zimmermann is an academic researcher from University of Graz. The author has contributed to research in topics: Autophagy & Spermidine. The author has an hindex of 16, co-authored 27 publications receiving 1590 citations. Previous affiliations of Andreas Zimmermann include Medical University of Graz.
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Journal ArticleDOI
Cardioprotection and lifespan extension by the natural polyamine spermidine
Tobias Eisenberg,Mahmoud Abdellatif,Sabrina Schroeder,Uwe Primessnig,Uwe Primessnig,Slaven Stekovic,Tobias Pendl,Alexandra Harger,Alexandra Harger,Julia Schipke,Andreas Zimmermann,Albrecht Schmidt,Mingming Tong,Christoph Ruckenstuhl,Christopher Dammbrueck,Angelina S. Gross,Viktoria Herbst,Christoph Magnes,Gert Trausinger,Sophie H. Narath,Andreas Meinitzer,Zehan Hu,Zehan Hu,Alexander H. Kirsch,Kathrin Eller,Didac Carmona-Gutierrez,Sabrina Büttner,Sabrina Büttner,Federico Pietrocola,Oskar Knittelfelder,Emilie Schrepfer,Patrick Rockenfeller,Patrick Rockenfeller,Corinna Simonini,Alexandros Rahn,Marion Horsch,Kristin Moreth,Johannes Beckers,Helmut Fuchs,Valerie Gailus-Durner,Frauke Neff,Dirk Janik,Birgit Rathkolb,Jan Rozman,Martin Hrabé de Angelis,Tarek Moustafa,Tarek Moustafa,Guenter Haemmerle,Manuel Mayr,Peter Willeit,Peter Willeit,Marion von Frieling-Salewsky,Burkert Pieske,Burkert Pieske,Luca Scorrano,Thomas R. Pieber,Thomas R. Pieber,Raimund Pechlaner,Johann Willeit,Stephan J. Sigrist,Stephan J. Sigrist,Wolfgang A. Linke,Christian Mühlfeld,Junichi Sadoshima,Joern Dengjel,Joern Dengjel,Stefan Kiechl,Guido Kroemer,Simon Sedej,Frank Madeo +69 more
TL;DR: It is shown that oral supplementation of the natural polyamine spermidine extends the lifespan of mice and exerts cardioprotective effects, reducing cardiac hypertrophy and preserving diastolic function in old mice, and suggests a new and feasible strategy for protection against cardiovascular disease.
Journal ArticleDOI
Essential role for autophagy in life span extension
TL;DR: Experimental findings indicating that inhibition of the major nutrient and growth-related signaling pathways as well as the upregulation of anti-aging pathways mediate life span extension via the induction of autophagy are reviewed.
Journal ArticleDOI
Nucleocytosolic depletion of the energy metabolite acetyl-coenzyme a stimulates autophagy and prolongs lifespan.
Tobias Eisenberg,Sabrina Schroeder,Aleksandra Andryushkova,Tobias Pendl,Victoria Küttner,Anuradha Bhukel,Anuradha Bhukel,Guillermo Mariño,Guillermo Mariño,Guillermo Mariño,Federico Pietrocola,Federico Pietrocola,Federico Pietrocola,Alexandra Harger,Alexandra Harger,Andreas Zimmermann,Tarek Moustafa,Adrian Sprenger,Evelyne Jany,Sabrina Büttner,Didac Carmona-Gutierrez,Christoph Ruckenstuhl,Julia Ring,Wieland Reichelt,Katharina Schimmel,Tina Leeb,Claudia Moser,Stefanie Schatz,Lars P. Kamolz,Christoph Magnes,Frank Sinner,Frank Sinner,Simon Sedej,Kai-Uwe Fröhlich,Gábor Juhász,Thomas R. Pieber,Thomas R. Pieber,Jörn Dengjel,Stephan J. Sigrist,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +41 more
TL;DR: It is shown that nucleocytosolic acetyl-coenzyme A (AcCoA) production is a metabolic repressor of autophagy during aging in yeast, and brain-specific knockdown of Drosophila AcCoA synthetase was sufficient to enhance autophagic protein clearance and prolong lifespan.
Journal ArticleDOI
Guidelines and recommendations on yeast cell death nomenclature
Didac Carmona-Gutierrez,Maria A. Bauer,Andreas Zimmermann,Andrés Aguilera,Nicanor Austriaco,Kathryn R. Ayscough,Rena Balzan,Shoshana Bar-Nun,Antonio Barrientos,Peter Belenky,Marc Blondel,Ralf J. Braun,Michael Breitenbach,William Wc Burhans,Sabrina Büttner,Sabrina Büttner,Duccio Cavalieri,Michael Chang,Katrina Kf Cooper,Manuela Côrte-Real,Vítor Costa,Vítor Costa,Christophe Cullin,Ian W. Dawes,Jörn Dengjel,Martin Mb Dickman,Tobias Eisenberg,Birthe Fahrenkrog,Nicolas Fasel,Kai-Uwe Fröhlich,Ali Gargouri,Sergio Giannattasio,Paola Goffrini,Campbell W. Gourlay,Chris M. Grant,Michael Mt Greenwood,Nicoletta Guaragnella,Thomas Heger,Jürgen J. Heinisch,Eva Herker,Johannes M. Herrmann,Sebastian J. Hofer,Antonio Jiménez-Ruiz,Helmut Jungwirth,Katharina Kainz,Dimitrios P. Kontoyiannis,Paula Ludovico,Paula Ludovico,Stéphen Manon,Enzo Martegani,Cristina Mazzoni,Lynn La Megeney,Lynn La Megeney,Christa Meisinger,Jens Nielsen,Jens Nielsen,Thomas Nyström,Heinz Hd Osiewacz,Tiago Tf Outeiro,Hay-Oak Park,Tobias Pendl,Dina Petranovic,Stéphane Picot,Peter Polčic,Ted Powers,Mark Ramsdale,Mark Rinnerthaler,Patrick Rockenfeller,Patrick Rockenfeller,Christoph Ruckenstuhl,Raffael Schaffrath,María Segovia,Fedor Ff Severin,Amir Sharon,Stephan J. Sigrist,Cornelia Sommer-Ruck,Maria João Sousa,Johan Jm Thevelein,Karin Thevissen,Vladimir I. Titorenko,Michel Mb Toledano,Mick F. Tuite,F-Nora Vögtle,Benedikt Westermann,Joris Winderickx,Silke Wissing,Stefan Wölfl,Zhaojie J Zhang,Richard Y. Zhao,Bing Zhou,Lorenzo Galluzzi,Lorenzo Galluzzi,Guido Kroemer,Frank Madeo +93 more
TL;DR: Unified criteria for the definition of accidental, regulated, and programmed forms of cell death in yeast based on a series of morphological and biochemical criteria are proposed.
Journal ArticleDOI
The flavonoid 4,4′-dimethoxychalcone promotes autophagy-dependent longevity across species
Didac Carmona-Gutierrez,Andreas Zimmermann,Andreas Zimmermann,Katharina Kainz,Federico Pietrocola,Guo Chen,Silvia Maglioni,Alfonso Schiavi,Jihoon Nah,Sara Mertel,Christine B. Beuschel,Francesca Castoldi,Valentina Sica,Gert Trausinger,Reingard Raml,Cornelia Sommer,Sabrina Schroeder,Sebastian J. Hofer,Maria A. Bauer,Tobias Pendl,Jelena Tadic,Christopher Dammbrueck,Zehan Hu,Christoph Ruckenstuhl,Tobias Eisenberg,Sylvère Durand,Sylvère Durand,Noélie Bossut,Noélie Bossut,Fanny Aprahamian,Fanny Aprahamian,Mahmoud Abdellatif,Simon Sedej,David Enot,David Enot,Heimo Wolinski,Jörn Dengjel,Oliver Kepp,Christoph Magnes,Frank Sinner,Frank Sinner,Thomas R. Pieber,Thomas R. Pieber,Junichi Sadoshima,Natascia Ventura,Stephan J. Sigrist,Stephan J. Sigrist,Guido Kroemer,Frank Madeo +48 more
TL;DR: It is demonstrated that DMC extends lifespan and promotes health in multiple organisms by inducing autophagy and is identified in the plant Angelica keiskei koidzumi, to which longevity- and health-promoting effects are ascribed in Asian traditional medicine.