M
Mariela M. Marani
Researcher at National Scientific and Technical Research Council
Publications - 35
Citations - 432
Mariela M. Marani is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Antimicrobial peptides & Peptide. The author has an hindex of 11, co-authored 30 publications receiving 364 citations. Previous affiliations of Mariela M. Marani include University of Porto & University of Buenos Aires.
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Journal ArticleDOI
Screening of one-bead-one-peptide combinatorial library using red fluorescent dyes. Presence of positive and false positive beads.
Mariela M. Marani,María Camila Martínez Ceron,Silvana L. Giudicessi,Eliandre de Oliveira,Simon Côté,Rosa Erra-Balsells,Fernando Albericio,Osvaldo Cascone,Silvia A. Camperi +8 more
TL;DR: An OBOC peptide library screening using streptavidin (SA) as probe protein, labeled with a red fluorescent dye and using the COPAS BIO-BEAD flow sorting equipment to separate fluorescent from nonfluorescent beads, finding false positive beads were rich in Leu/Ileu, His, Phe, and Tyr.
Journal ArticleDOI
Structure and function of a novel antioxidant peptide from the skin of tropical frogs.
Eder Alves Barbosa,Ana Oliveira,Alexandra Plácido,Renato Socodato,Camila C. Portugal,Ana Carolina Mafud,Alicia S. Ombredane,Daniel C. Moreira,Nuno Vale,Lucinda J. Bessa,Graziella Anselmo Joanitti,Cláudia Alves,Paula Gomes,Cristina Delerue-Matos,Yvonne Primerano Mascarenhas,Mariela M. Marani,João B. Relvas,Manuela Pintado,José Roberto S. A. Leite,José Roberto S. A. Leite +19 more
TL;DR: Results support the application of the peptide for neuroprotection and present a low cytotoxicity and suppressed menadione‐induced redox imbalance when tested with fibroblast in culture.
Journal ArticleDOI
An efficient strategy for the preparation of one-bead-one-peptide libraries on a new biocompatible solid support
Silvia A. Camperi,Mariela M. Marani,Nancy B. Iannucci,Simon Côté,Fernando Albericio,Osvaldo Cascone +5 more
TL;DR: A new strategy for the preparation of one-bead-one-peptide libraries compatible with solid-phase screening and subsequent detachment of the peptide from the resin for sequence determination by mass spectrometry is described.
Journal ArticleDOI
Characterization and Biological Activities of Ocellatin Peptides from the Skin Secretion of the Frog Leptodactylus pustulatus.
Mariela M. Marani,Flávio Santos Dourado,Patrick Veras Quelemes,Alyne Rodrigues de Araújo,Márcia Luana Gomes Perfeito,Eder Alves Barbosa,Leiz Maria Costa Véras,Andreia Coelho,Andreia Coelho,Etielle B. Andrade,Etielle B. Andrade,Peter Eaton,João Paulo Figueiró Longo,Ricardo Bentes Azevedo,Cristina Delerue-Matos,José Roberto S. A. Leite +15 more
TL;DR: Eight new peptides were isolated from the skin secretion of the frog Leptodactylus pustulatus and their amino acid sequences determined by de novo sequencing and by cDNA cloning and demonstrate the secretion of mature peptides derived from a pre-pro-peptide structure.
Journal ArticleDOI
Affinity chromatography based on a combinatorial strategy for rerythropoietin purification.
María C. Martínez-Ceron,Mariela M. Marani,Marta Taules,Marina Etcheverrigaray,Fernando Albericio,X Osvaldo Cascone,Silvia A. Camperi +6 more
TL;DR: Small peptides containing fewer than 10 amino acids are promising ligand candidates with which to build affinity chromatographic systems for industrial protein purification and their affinity to recombinant human erythropoietin (rhEPO) is identified.