M
Mark J. Edwards
Researcher at St George's, University of London
Publications - 398
Citations - 20432
Mark J. Edwards is an academic researcher from St George's, University of London. The author has contributed to research in topics: Dystonia & Psychogenic disease. The author has an hindex of 63, co-authored 365 publications receiving 16293 citations. Previous affiliations of Mark J. Edwards include St George’s University Hospitals NHS Foundation Trust & University College London.
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Journal ArticleDOI
The epsilon-sarcoglycan gene in myoclonic syndromes
Enza Maria Valente,Mark J. Edwards,Pablo Mir,A. DiGiorgio,S Salvi,Mark David McGregor Davis,Nickole Russo,M Bozi,H. T. Kim,Giovanni Pennisi,Niall Quinn,Bruno Dallapiccola,Kailash P. Bhatia +12 more
TL;DR: Mutations in the epsilon-sarcoglycan gene (SGCE) are found in six (21%) of the 29 patients with essential myoclonus and myoclonic dystonia, but the full spectrum of the phenotype may not be fully defined.
Journal ArticleDOI
Distinguishing the Central Drive to Tremor in Parkinson's Disease and Essential Tremor
John-Stuart Brittain,Hayriye Cagnan,Arpan R. Mehta,Tabish A. Saifee,Mark J. Edwards,Peter Brown +5 more
TL;DR: It is demonstrated that parkinsonian tremors and ETs result from distinct patterns of interactions between neural oscillators, whose disruption in PD and ET dictates how patients respond to empirical, and potentially therapeutic, interventions that interact with their underlying pathophysiology.
Journal ArticleDOI
Functional cognitive disorder: dementia’s blind spot
Harriet A. Ball,Laura McWhirter,Clive Ballard,Rohan Bhome,Daniel Blackburn,Mark J. Edwards,Stephen M. Fleming,Nick C. Fox,Robert Howard,Jonathan Huntley,Jeremy D. Isaacs,Jeremy D. Isaacs,Andrew J Larner,Timothy R Nicholson,Catherine Pennington,Norman Poole,Gary Price,Jason P Price,Markus Reuber,Craig W. Ritchie,Martin N. Rossor,Jonathan M. Schott,Tiago Teodoro,Tiago Teodoro,Annalena Venneri,Jon Stone,Alan Carson +26 more
TL;DR: A preliminary definition of functional neurological disorder-cognitive subtype is presented, its position in relation to other cognitive diagnoses and emerging biomarkers, clinical features that can lead to positive diagnosis, and red flags that should prompt consideration of alternative diagnoses are presented.
Journal ArticleDOI
The endophenotype and the phenotype: Temporal discrimination and adult-onset dystonia
Michael Hutchinson,Okka Kimmich,Anna Molloy,Robert Whelan,Fiona Molloy,Timothy Lynch,Daniel G. Healy,Cathal Walsh,Mark J. Edwards,Laurie J. Ozelius,Richard B. Reilly,Sean O'Riordan +11 more
TL;DR: It is hypothesized that abnormal temporal discrimination reflects dysfunction in an evolutionarily conserved subcortical‐basal ganglia circuit for the detection of salient novel environmental change in adult‐onset primary torsion dystonia.
Journal ArticleDOI
Outcome measurement in functional neurological disorder: a systematic review and recommendations
Susannah Pick,David G. Anderson,Ali A. Asadi-Pooya,Ali A. Asadi-Pooya,Selma Aybek,Gaston Baslet,Bastiaan R. Bloem,Abigail Bradley-Westguard,Richard J. Brown,Alan Carson,Trudie Chalder,Maria Damianova,Anthony S. David,Mark J. Edwards,Steven A. Epstein,Alberto J. Espay,Béatrice Garcin,Laura H. Goldstein,Mark Hallett,Joseph Jankovic,Eileen M. Joyce,Richard A A Kanaan,Roxanne Keynejad,Kasia Kozlowska,Kathrin LaFaver,W. Curt LaFrance,Anthony E. Lang,Alexander Lehn,Sarah C Lidstone,Carine W. Maurer,Bridget Mildon,Francesca Morgante,Lorna Myers,Clare Nicholson,Glenn Nielsen,David L. Perez,Stoyan Popkirov,Markus Reuber,Karen S. Rommelfanger,Petra Schwingenshuh,Tereza Serranová,Paul Shotbolt,Glenn T. Stebbins,Jon Stone,Marina A. J. Tijssen,Michele Tinazzi,Timothy R Nicholson +46 more
TL;DR: There are few well-validated FND-specific outcome measures and existing outcome measures, known to be reliable, valid and responsive in FND or closely related populations, are recommended to be used to capture key outcome domains.