M
Markus R. Wenk
Researcher at National University of Singapore
Publications - 332
Citations - 25285
Markus R. Wenk is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Lipid metabolism. The author has an hindex of 81, co-authored 292 publications receiving 21516 citations. Previous affiliations of Markus R. Wenk include Swiss Tropical and Public Health Institute & University of Geneva.
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Journal ArticleDOI
Trans-Golgi Network and Endosome Dynamics Connect Ceramide Homeostasis with Regulation of the Unfolded Protein Response and TOR Signaling in Yeast
Carl J. Mousley,Kimberly Tyeryar,Kristina E. Ile,Gabriel Schaaf,Renee L. Brost,Charles Boone,Xue Li Guan,Markus R. Wenk,Vytas A. Bankaitis +8 more
TL;DR: Combinatorial Sec14/Tlg2 dysfunction evokes inappropriate turnover of complex sphingolipids in endosomes, and this turnover is potentiation of ceramide-activated phosphatase-mediated down-regulation of the UPR.
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The Stem Region of Premembrane Protein Plays an Important Role in the Virus Surface Protein Rearrangement during Dengue Maturation
Qian Zhang,Cornelia Hunke,Yin Hoe Yau,Vernon Seow,Sumarlin Lee,Lukas B. Tanner,Xue Li Guan,Markus R. Wenk,Guntur Fibriansah,Pau Ling Chew,Petra Kukkaro,Goran Biuković,Pei Yong Shi,Susana Geifman Shochat,Gerhard Grüber,Shee-Mei Lok +15 more
TL;DR: The results suggest that the prM-stem region forms a tight association with the virus membrane and attracts the associated E protein in the low pH environment of exosomes, which will lead to the surface protein rearrangement observed during maturation.
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The synaptojanin-like protein Inp53/Sjl3 functions with clathrin in a yeast TGN-to-endosome pathway distinct from the GGA protein- dependent pathway
Seon-Ah Ha,Javad Torabinejad,Daryll B. DeWald,Markus R. Wenk,Louise Lucast,Pietro De Camilli,Richard A. Newitt,Ruedi Aebersold,Steven F. Nothwehr +8 more
TL;DR: The results suggest that Inp53p and AP-1/clathrin act together in a T GN-to-early endosome pathway distinct from the direct TGN- to-PVC pathway mediated by GGA/ clathrin.
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Peculiarities of host cholesterol transport to the unique intracellular vacuole containing Toxoplasma.
Alfica Sehgal,Silvana Bettiol,Marc Pypaert,Markus R. Wenk,Achim J. Kaasch,Ira J. Blader,Keith A. Joiner,Isabelle Coppens +7 more
TL;DR: A vesicular transport system from host endolysosomes to the PV, and a requirement for PV membrane and parasite plasma membrane proteins in C delivery to T. gondii are supported.
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Comprehensive analysis of phospholipids and glycolipids in the opportunistic pathogen Enterococcus faecalis
Rafi Rashid,Amaury Cazenave-Gassiot,Iris H. Gao,Zeus J. Nair,Jaspal Kaur Kumar,Liang Gao,Kimberly A. Kline,Markus R. Wenk +7 more
TL;DR: This lipidome map is the first comprehensive analysis of membrane phospholipids and glycolipids in the important human pathogen E. faecalis, for which antimicrobial resistance and altered lipid homeostasis have been intimately linked.