Markus R. Wenk

TL;DR: The isolation of the dynamic metabolon that catalyzes the formation of the cyanogenic glucoside dhurrin, a defense compound produced in sorghum plants is reported, which demonstrated the importance of membrane surface charge and the presence of the glucosyltransferase for metabolic channeling.

TL;DR: It is shown that rhinovirus replication depends on host factors driving phosphatidylinositol 4-phosphate (PI4P)-cholesterol counter-currents at viral replication membranes, and data support a PI4P-ch cholesterol counter-flux model for rhinOVirus replication.

TL;DR: Healthy subjects showed substantial variation in the timing and strength of rhythms across different lipid species, suggesting that there are different circadian metabolic phenotypes in the general population and potential implications for lipid metabolism disorders linked to circadian clock disruption.

TL;DR: It is shown that cyclin-dependent kinase 5 (Cdk5) phosphorylates synaptojanin 1 and regulates its function both in vitro and in intact synaptosomes, and suggests that Cdk5 and calcineurin may have an antagonistic role in the regulation of synaptobic recruitment and activity, and therefore in theregulation of phosphatidylinositol 4,5-bisphosphate turnover at synapses.

TL;DR: The results establish a link between transport of DHA and LPCs by MFSD2A and human brain growth and function, presenting the first evidence of monogenic disease related to transport ofDHA in humans.