Markus R. Wenk

TL;DR: A THL analog and activity-based protein profiling is used to identify target proteins after enrichment from whole cell lysates of Mycobacterium bovis Bacillus Calmette-Guérin cultured under replicating and non-replicating conditions to define the target spectrum of THL in a biological species with particularly diverse lipid metabolic pathways.

TL;DR: The Lipidomics Standards Initiative (LSI) as discussed by the authors is a community-based endeavor for the coordination of development of these best practice guidelines in lipidomics, and is embedded within the International lipidomics Society (ILS).

TL;DR: Excess ocular surface phospholipase activity detrimental to tear film stability could be alleviated by eyelid warming alone without application of steroids and tear OAHFAs are identified as suitable markers to monitor treatment response in MGD.

TL;DR: The decrease in choline plasmalogen levels during sleep deprivation is consistent with prior work demonstrating that these lipids are susceptible to degradation by oxidative stress, and the increase in phosphatidylcholines and triacylglycerides suggests that sleep loss might modulate lipid metabolism, which has potential implications for metabolic health in individuals who do not achieve adequate sleep.

TL;DR: Using fluorescence correlation spectroscopy to assay the mobility of SBD in live cells, it is shown that SBD's behavior at the plasma membrane is similar to that of the previously described raft marker cholera toxin B, displaying both a fast and a slow component.