M
Markus R. Wenk
Researcher at National University of Singapore
Publications - 332
Citations - 25285
Markus R. Wenk is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Lipid metabolism. The author has an hindex of 81, co-authored 292 publications receiving 21516 citations. Previous affiliations of Markus R. Wenk include Swiss Tropical and Public Health Institute & University of Geneva.
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Journal ArticleDOI
Implications for lipids during replication of enveloped viruses.
TL;DR: This review aims to present a unifying view of the widely diverse strategies used by enveloped viruses at distinct stages of their replication cycles.
Journal ArticleDOI
Homozygous mutation in MFSD2A , encoding a lysolipid transporter for docosahexanoic acid, is associated with microcephaly and hypomyelination
Tamar Harel,Debra Q Y Quek,Bernice H. Wong,Amaury Cazenave-Gassiot,Markus R. Wenk,Hao Fan,Hao Fan,Itai Berger,Dorit Shmueli,Avraham Shaag,David L. Silver,Orly Elpeleg,Shimon Edvardson +12 more
TL;DR: The aggregate data of MFSD2A-associated genotypes and phenotypes suggest that additional factors, such as nutritional supplementation or modifying genetic factors, may modulate the severity of disease and call for consideration of treatment options for affected individuals.
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Chronic exposure to U18666A is associated with oxidative stress in cultured murine cortical neurons.
Chor Hui Vivien Koh,Matthew Whiteman,Qiao-Xin Li,Qiao-Xin Li,Barry Halliwell,Andrew M. Jenner,Boon Seng Wong,Katrina M. Laughton,Katrina M. Laughton,Markus R. Wenk,Colin L. Masters,Colin L. Masters,Philip M Beart,Ora Bernard,Nam Sang Cheung +14 more
TL;DR: The association of neuronal apoptosis with oxidative stress and Aβ accumulation may provide clues to the pathogenesis of Alzheimer's disease, as well as the role oxidative stress plays in other neurodegenerative diseases.
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Docosapentaenoic acid (DPA) is a critical determinant of cubic membrane formation in amoeba Chaos mitochondria
TL;DR: Evidence derived from studies in the amoeba Chaos is provided that indicates a structural role for ω‐6 DPA in cell membrane organization, which may help to explain the multiple diverse effects of VLC‐PUFA in healthy and diseased states.
Journal ArticleDOI
LRH-1 regulates hepatic lipid homeostasis and maintains arachidonoyl phospholipid pools critical for phospholipid diversity
Diego A Miranda,William C. Krause,Amaury Cazenave-Gassiot,Miyuki Suzawa,Hazel S. Escusa,Juat Chin Foo,Diyala S. Shihadih,Andreas Stahl,Mark Fitch,Edna Nyangau,Marc K. Hellerstein,Markus R. Wenk,David L. Silver,Holly A. Ingraham +13 more
TL;DR: A role for the phospholipid sensor LRH-1 is revealed in maintaining adequate pools of hepatic AAospholipids, further supporting the idea that phospholIPid diversity is an important contributor to healthy hepatic lipid storage.