M
Markus R. Wenk
Researcher at National University of Singapore
Publications - 332
Citations - 25285
Markus R. Wenk is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Lipid metabolism. The author has an hindex of 81, co-authored 292 publications receiving 21516 citations. Previous affiliations of Markus R. Wenk include Swiss Tropical and Public Health Institute & University of Geneva.
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Journal ArticleDOI
Lipidomic profiling of human serum enables detection of pancreatic cancer
Denise Wolrab,Robert Jirásko,Eva Cífková,Marcus Höring,Dinglian Mei,Michaela Chocholoušková,Ondřej Peterka,Jakub Idkowiak,Tereza Hrnciarova,Ladislav Kuchar,Robert Ahrends,Radana Brumarová,David Friedecký,Gabriel Vivo-Truyols,Pavel Škrha,Jan Škrha,Radek Kucera,Bohuslav Melichar,Gerhard Liebisch,Ralph Burkhardt,Markus R. Wenk,Amaury Cazenave-Gassiot,P. Karasek,Ivo Novotný,Kristína Greplová,Roman Hrstka,Michal Holčapek +26 more
TL;DR: In this article , a comprehensive mass spectrometric determination of a wide range of serum lipids reveals statistically significant differences between pancreatic cancer patients and healthy controls, as visualized by multivariate data analysis.
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Expanding coincident signaling by PTEN through its inositol 1,3,4,5,6-pentakisphosphate 3-phosphatase activity.
TL;DR: The physiological significance of these studies in relation to recent work showing that dephosphorylation of Ins(1,3,4,5,6)P5 to inositol 1, 4, 5,6‐tetrakisphosphate is a cell signaling event is discussed.
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Click-based synthesis and proteomic profiling of lipstatin analogues
TL;DR: Using click chemistry to enable both structural diversity and proteome profiling within a natural product derived library, two out of nineteen lipstatin analogues showed similar activity to Orlistat against fatty acid synthase (FAS), but with an improved ability to induce tumour cell death.
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Transcriptomic and lipidomic profiles of glycerolipids during Arabidopsis flower development
Yuki Nakamura,Norman Z. W. Teo,Guanghou Shui,Guanghou Shui,Christine H. L. Chua,Wei Fun Cheong,Sriram Parameswaran,Ryota Koizumi,Hiroyuki Ohta,Markus R. Wenk,Markus R. Wenk,Toshiro Ito +11 more
TL;DR: The authors' concurrent profiling of glycerolipids and relevant metabolic gene expression revealed distinct metabolic pathways stimulated at different stages of flower development in Arabidopsis, suggesting a role for phosphatidic acid in flower development.
Journal ArticleDOI
ABCA8 Regulates Cholesterol Efflux and High-Density Lipoprotein Cholesterol Levels
Laia Trigueros-Motos,Julian C. van Capelleveen,Federico Torta,David Castano,Lin-Hua Zhang,Ee Chu Chai,Martin H. Kang,Lidiya G. Dimova,Alinda W. M. Schimmel,Ian Tietjen,Chris Radomski,Liang Juin Tan,Chung Hwee Thiam,Pradeep Narayanaswamy,Daniel Heqing Wu,Fabian Dorninger,Gopala K. Yakala,Amina Barhdadi,Veronique Angeli,Marie-Pierre Dubé,Johannes Berger,Geesje M. Dallinga-Thie,Uwe J. F. Tietge,Markus R. Wenk,Michael R. Hayden,G. Kees Hovingh,Roshni R. Singaraja +26 more
TL;DR: The role of ABCA8 is investigated in cholesterol efflux and in regulating HDLc levels in humans and mice to find out how it interacts with adenosine triphosphate–binding cassette transporter A1 and further potentiates A1–mediatedolesterol efflux.