Markus R. Wenk

TL;DR: A comprehensive lipidome of meibum from individuals of an Asian ethnicity is presented, for the first time, which can potentially offer new insights into the higher prevalence of dysfunctional tear syndrome observed amongst Asian populations.

TL;DR: Isothermal titration calorimetry studies of Tir–CesT and enzymatic activity profiles of SigD–SigE indicate that the effector proteins are not globally unfolded in the presence of their cognate chaperones, and variable, delocalized hydrophobic surfaces observed on the chaperone homodimers are responsible for specific binding to a particular effector protein.

TL;DR: It is shown that phospholipase D1 (PLD1), which is primarily associated with the endosomal system, partially relocalizes to the outer membrane of autophagosome-like structures upon nutrient starvation, establishing a role for PLD1 in autophagy.

TL;DR: A mechanism through which TMEM24, a lipid transport protein that concentrates at endoplasmic reticulum–plasma membrane contact sites, regulates the pulsatility of cytosolic Ca2+ and phosphoinositide signaling is reported, which regulates pulsatile insulin secretion during the slow insulin release phase.

TL;DR: The data indicate that changes in lipid metabolism occur in the Parkinson's disease visual cortex in the absence of obvious pathology, which suggests that normalization of lipid metabolism and/or oxidative stress status in the visual cortex may represent a novel route for treatment of non-motor symptoms, such as visual hallucinations, that are experienced by a majority of Parkinson's patients.