M
Markus R. Wenk
Researcher at National University of Singapore
Publications - 332
Citations - 25285
Markus R. Wenk is an academic researcher from National University of Singapore. The author has contributed to research in topics: Medicine & Lipid metabolism. The author has an hindex of 81, co-authored 292 publications receiving 21516 citations. Previous affiliations of Markus R. Wenk include Swiss Tropical and Public Health Institute & University of Geneva.
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Journal ArticleDOI
Concurrent lipidomics and proteomics on malignant plasma cells from multiple myeloma patients: Probing the lipid metabolome.
Ahmed Mohamed,Joel Collins,Hui Jiang,Jeffrey Molendijk,Jeffrey Molendijk,Thomas Stoll,Thomas Stoll,Federico Torta,Markus R. Wenk,Robert Bird,Paula Marlton,Paula Marlton,Peter Mollee,Peter Mollee,Kate A. Markey,Kate A. Markey,Kate A. Markey,Michelle M. Hill,Michelle M. Hill +18 more
TL;DR: This study establishes the feasibility and workflow to conduct integrated lipidomics and proteomics analyses on patient-derived plasma cells and revealed enriched correlation of PC, ceramide, cardiolipin, arachidonic acid and cholesterol metabolism pathways to be exclusively correlated among relapsed but not in newly-diagnosed patients.
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TDP-43 mediates SREBF2-regulated gene expression required for oligodendrocyte myelination.
Wan Yun Ho,Jer-Cherng Chang,Kenneth Lim,Amaury Cazenave-Gassiot,Aivi T. Nguyen,Juat Chin Foo,Sneha Muralidharan,Ashley Viera-Ortiz,Sarah J M Ong,Jin Hui Hor,Ira Agrawal,Shawn Hoon,Olubankole Aladesuyi Arogundade,María Jesús Delgado Rodríguez,Su Min Lim,Su Min Lim,Seung Hyun Kim,John Ravits,Shi-Yan Ng,Shi-Yan Ng,Markus R. Wenk,Edward B. Lee,Greg Tucker-Kellogg,Shuo-Chien Ling +23 more
TL;DR: In this paper, the authors demonstrate that TDP-43, the pathological signature protein for amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), influences cholesterol metabolism in oligodendrocytes.
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Changes of tear lipid mediators after eyelid warming or thermopulsation treatment for meibomian gland dysfunction.
Yohannes Abere Ambaw,David Fuchs,Manfred Raida,Nebyat Tadlo Mazengia,Federico Torta,Craig E. Wheelock,Markus R. Wenk,Louis Tong +7 more
TL;DR: Overall, MGD therapy reduced pro-inflammatory molecules generated by lipoxygenase and oxidative stress, suggesting reduction in oxidative action.
Journal ArticleDOI
Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis
TL;DR: Using an orthogonal protecting group approach to resolve racemic myo-inositol directly as its D-mannoside, a [2+n]-glycan/phosphatidylation strategy is reported to assemble a bis-palmityl, tuberculostearyl form of phosph atidyl-myo- inositol dimannoside (PIM-2).
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LICAR: An Application for Isotopic Correction of Targeted Lipidomic Data Acquired with Class-Based Chromatographic Separations Using Multiple Reaction Monitoring
TL;DR: In this paper, an algorithm for isotopic correction in class-based separation using MRM, provided in the R programming language, extracts relevant structural information from MRM transitions to apply adequate isotope correction factors.