Martin Hölzer

TL;DR: This work used a full-length, direct RNA sequencing (DRS) approach based on nanopores to characterize viral RNAs produced in cells infected with a human coronavirus, and paves the way for haplotype-based analyses of viral quasispecies by showing the feasibility of intra-sample haplotype separation.

TL;DR: A large-scale comparative study in which 10 de novo assembly tools are applied to 9 RNA-Seq data sets spanning different kingdoms of life, finding that Trinity, SPAdes, and Trans-ABySS, followed by Bridger and SOAPdenovo-Trans, generally outperformed the other tools compared.

TL;DR: Bioinformatics workflows and tools for the routine detection of SARS-CoV-2 infection, the reliable analysis of sequencing data, the tracking of the COVID-19 pandemic and evaluation of containment measures, the study of coronavirus evolution, the discovery of potential drug targets and development of therapeutic strategies are reviewed.

TL;DR: Bioinformatics workflows and tools for the routine detection of SARS-CoV-2 infection, the reliable analysis of sequencing data, the tracking of the COVID-19 pandemic and evaluation of containment measures, the study of coronavirus evolution, the discovery of potential drug targets and development of therapeutic strategies are covered.

TL;DR: It is shown that aged hematopoietic stem and progenitor cells (HSPCs) exhibit increased ground‐stage NF‐&kgr;B activity, which enhances their responsiveness to undergo differentiation and loss of self‐renewal in response to inflammation.