Hepatitis C Virus Core Protein Inhibits Mitochondrial Electron Transport and Increases Reactive Oxygen Species (ROS) Production
Masaaki Korenaga,Ting Wang,Yanchun Li,Lori A. Showalter,Tehsheng Chan,Jiaren Sun,Steven A. Weinman +6 more
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TLDR
Results suggest that interaction of core protein with mitochondria and subsequent oxidation of the glutathione pool and complex I inhibition may be an important cause of the oxidative stress seen in chronic hepatitis C.About:
This article is published in Journal of Biological Chemistry.The article was published on 2005-11-11 and is currently open access. It has received 392 citations till now. The article focuses on the topics: Coenzyme Q – cytochrome c reductase & Reactive oxygen species.read more
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Decoding cell death signals in liver inflammation.
Catherine Brenner,Catherine Brenner,Lorenzo Galluzzi,Lorenzo Galluzzi,Oliver Kepp,Oliver Kepp,Guido Kroemer +6 more
TL;DR: The cellular and molecular mechanisms that account for the most deleterious effect of hepatic inflammation at the cellular level are discussed, that is, the initiation of a massive cell death response among hepatocytes.
Journal ArticleDOI
Liver Fibrosis: Mechanistic Concepts and Therapeutic Perspectives
TL;DR: In this paper, the authors summarized cellular drivers and molecular mechanisms of fibrogenesis in chronic liver diseases and discuss their impact for the development of urgently needed anti-fibrotic therapies.
Journal ArticleDOI
Role of free radicals in liver diseases.
TL;DR: The capability of ethanol to increase both ROS/RNS and peroxidation of lipids, DNA, and proteins was demonstrated in a variety of systems, cells, and species, including humans, and antioxidants have been proposed as an adjunct therapy for various liver diseases.
Journal ArticleDOI
Glutathione in liver diseases and hepatotoxicity.
Liyun Yuan,Neil Kaplowitz +1 more
TL;DR: The redox regulation either can switch on/off or regulate the threshold for some crucial events in these pathways, including TNF-alpha and Fas signaling, NF-kappaB, JNK and mitochondrial apoptotic pathways, are reviewed.
Journal ArticleDOI
The mitochondria-targeted anti-oxidant mitoquinone decreases liver damage in a phase II study of hepatitis C patients.
Edward Gane,Frank Weilert,David Orr,Geraldine F. Keogh,Michael K. Gibson,Michelle M. Lockhart,Chris Frampton,Kenneth Martin Taylor,Robin A.J. Smith,Michael P. Murphy +9 more
TL;DR: The mitochondria‐targeted anti‐oxidant mitoquinone combines a potent anti‐ oxidant with a lipophilic cation that causes it to accumulate several‐hundred fold within mitochondria in vivo.
References
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Journal ArticleDOI
Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection.
Michael W. Fried,Mitchell L. Shiffman,K. Rajender Reddy,C. Smith,George Marinos,Fernando L. Gonçales,Dieter Häussinger,Moisés Diago,Giampiero Carosi,Daniel Dhumeaux,Antonio Craxì,A. Lin,Joseph Hoffman,Jian Yu +13 more
TL;DR: In patients with chronic hepatitis C, once-weekly peginterferon alfa-2a plus ribavirin was tolerated as well as interferonAlfa- 2b plus Ribavirin and produced significant improvements in the rate of sustained virologic response, as compared with interfer on alfa -2b plus ribvirin or pegin terferonalfa-3a alone.
Journal ArticleDOI
Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial.
Michael P. Manns,John G. McHutchison,Stuart C. Gordon,Vinod K. Rustgi,Mitchell L. Shiffman,Robert Reindollar,Zachary Goodman,Kenneth Koury,Mei Hsiu Ling,Janice K. Albrecht +9 more
TL;DR: In patients with chronic hepatitis C, the most effective therapy is the combination of peginterferon alfa-2b 1.5 microg/kg per week plus ribavirin, and this randomised trial found that the benefit is mostly achieved in patients with HCV genotype 1 infections.
Journal ArticleDOI
The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
Alberto Boveris,Britton Chance +1 more
TL;DR: It is postulated that in addition to the well-known flavin reaction, formation of H( 2)O(2) may be due to interaction with an energy-dependent component of the respiratory chain at the cytochrome b level.
Journal ArticleDOI
Calcium, ATP, and ROS: a mitochondrial love-hate triangle
TL;DR: A "two-hit" hypothesis is developed, in which Ca(2+) plus another pathological stimulus can bring about mitochondrial dysfunction, and the delicate balance between the positive and negative effects of Ca( 2+) and the signaling events that perturb this balance is highlighted.
Book ChapterDOI
[7] Mitochondrial respiratory control and the polarographic measurement of ADP : O ratios
TL;DR: This chapter discusses the mitochondrial respiratory control and the polarographic measurement of ADP : O ratios and the principle of the oxygen electrode has been summarized, and the design of the vibrating oxygen electrode for use with speetrophotometric studies is illustrated.