Masahiro Fukasaka

TL;DR: Jdp2 plays pivotal roles in in vivo bone homeostasis and host defense by regulating osteoclast and neutrophil differentiation and directly suppresses its expression via inhibition of histone acetylation.

TL;DR: It is found that claudin-4 is expressed in nasal MALT, and OVA-C-CPE immunization activated both Th1 and Th2 responses, and nasal immunization showed anti-tumor activity in mice inoculated with Ova-expressing thymoma cells, indicating that the claudIn-4- targeting may be a potent strategy for nasal vaccination.

TL;DR: Netrin 1 treatment prevented bone erosion in an autoimmune arthritis model and age-related bone destruction, and the netrin 1-UNC5b axis is a novel therapeutic target for bone-destructive diseases.

TL;DR: TNFR-associated factor family member–associated NF-κB activator (TANK)–binding kinase 1 (TBK1) is critical for the activation of IFN regulatory factor 3 and type I IFN production upon virus infection but not TBK1-binding proteins, 5-azacytidine–induced gene 2 (AZI2), which can potentially be used to increase the efficiency of immunization by cDCs.

TL;DR: It is suggested that LPSpa can be used as an effective mucosal adjuvant to stimulate and activate local innate immune cells to improve and enhance mucosal vaccine potency against various pathogens.