S
Sarang Tartey
Researcher at St. Jude Children's Research Hospital
Publications - 17
Citations - 861
Sarang Tartey is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Innate immune system & Inflammation. The author has an hindex of 11, co-authored 16 publications receiving 653 citations. Previous affiliations of Sarang Tartey include Osaka University & Prevention Institute.
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Journal ArticleDOI
Regnase-1 and Roquin Regulate a Common Element in Inflammatory mRNAs by Spatiotemporally Distinct Mechanisms
Takashi Mino,Yasuhiro Murakawa,Akira Fukao,Alexis Vandenbon,Hans-Hermann Wessels,Daisuke Ori,Takuya Uehata,Sarang Tartey,Shizuo Akira,Yutaka Suzuki,Carola G. Vinuesa,Uwe Ohler,Daron M. Standley,Markus Landthaler,Toshinobu Fujiwara,Osamu Takeuchi +15 more
TL;DR: It is shown that, although Regnase-1 and Roquin regulate an overlapping set of mRNAs via a common stem-loop structure, they function in distinct subcellular locations: ribosome/endoplasmic reticulum and processing-body/stress granules, respectively.
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Pathogen recognition and Toll-like receptor targeted therapeutics in innate immune cells
TL;DR: The recent advances in TLR signaling cross talks and the mechanism of pathogen recognition are discussed with special emphasis on the role of TLRs in tumor immunity and TLR-targeted therapeutics.
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Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.
Sarang Tartey,Kazufumi Matsushita,Alexis Vandenbon,Daisuke Ori,Tomoko Imamura,Takashi Mino,Daron M. Standley,Jules A. Hoffmann,Jean-Marc Reichhart,Shizuo Akira,Osamu Takeuchi,Osamu Takeuchi +11 more
TL;DR: It is shown that Akirin2, an evolutionarily conserved nuclear protein, bridges NF‐κB and the chromatin remodeling SWI/SNF complex by interacting with BRG1‐Associated Factor 60 (BAF60) proteins as well as IκB‐ζ, which forms a complex with the NF‐kkB p50 subunit.
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Differential role of the NLRP3 inflammasome in infection and tumorigenesis.
TL;DR: The rapidly expanding body of research on the expression and functions of NLRP3 in infections and cancers is explored and novel inhibitors targeting theNLRP3 inflammasome are outlined that could be developed as therapeutic alternatives to current anticancer treatment.
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Essential Roles of K63-Linked Polyubiquitin-Binding Proteins TAB2 and TAB3 in B Cell Activation via MAPKs
Daisuke Ori,Hiroki Kato,Hideki Sanjo,Sarang Tartey,Sarang Tartey,Takashi Mino,Shizuo Akira,Osamu Takeuchi,Osamu Takeuchi +8 more
TL;DR: It is demonstrated that TAB2 and TAB3 are essential for B cell activation leading to Ag-specific Ab responses, as well as B-1 and marginal zone B cell development, and that Tab2- and Tab3-mediated K63-linked polyubiquitin recognition controls B cellactivation via MAPKs, but not the TAK1/NF-κB axis.