Masahiro Murakami

TL;DR: This work reports a highly diastereo- and enantioselective synthesis of anti homoallylic alcohols from terminal alkynes via (E)-1-alkenylboronates based upon two catalytic reactions: a cationic iridium complex-catalyzed olefin transposition of (E-1-alksenyl Boronates and a chiral phosphoric acid-Catalyzed allylation reaction of aldehydes.

TL;DR: An efficient one-pot two-step procedure for asymmetric synthesis of piperidine-fused trans-cycloalkenes and a concerted mechanism is proposed for the latter thermal rearrangement reaction together with a closed transition state model.

TL;DR: New serine protease inhibitors, microviridins D, E and F, were isolated from the cyanobacterium Oscillatoria agardhii (NIES-204) and inhibitor structures were elucidated to be 1–3 by extensive 2D NMR data and chemical degradation.

TL;DR: Using aminoboranes bearing bulky amino groups, such as a diisopropylamino group, free secondary amines can be successfully used as the amino component in a three-component Mannich reaction with aldehydes and silyl ketene acetals.

TL;DR: Microviridios B and C were isolated from the freshwater blue-green alga Microcystis aeruginosa and these peptides inhibited elastase potently.