M
Masahiro Yamamoto
Researcher at Osaka University
Publications - 472
Citations - 36678
Masahiro Yamamoto is an academic researcher from Osaka University. The author has contributed to research in topics: Innate immune system & Immune system. The author has an hindex of 77, co-authored 434 publications receiving 33443 citations. Previous affiliations of Masahiro Yamamoto include Tokyo Medical and Dental University & National Institute of Radiological Sciences.
Papers
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Journal ArticleDOI
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
Hiroki Kato,Osamu Takeuchi,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Kosuke Matsui,Satoshi Uematsu,Andreas Jung,Taro Kawai,Ken Ishii,Osamu Yamaguchi,Kinya Otsu,Tohru Tsujimura,Chang-Sung Koh,Caetano Reis e Sousa,Yoshiharu Matsuura,Takashi Fujita,Shizuo Akira +17 more
TL;DR: It is found that RIG-I is essential for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus and Japanese encephalitis virus, whereas MDA5 is critical for picornavirus detection.
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Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway.
Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Katsuaki Hoshino,Tsuneyasu Kaisho,Hideki Sanjo,Osamu Takeuchi,Masanaka Sugiyama,Masaru Okabe,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that TRIF is essential for TLR3- and TLR4-mediated signaling pathways facilitating mammalian antiviral host defense and complete loss of nuclear factor kappa B activation in response toTLR4 stimulation is demonstrated.
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Cell type-specific involvement of RIG-I in antiviral response
Hiroki Kato,Shintaro Sato,Mitsutoshi Yoneyama,Masahiro Yamamoto,Satoshi Uematsu,Kosuke Matsui,Tohru Tsujimura,Kiyoshi Takeda,Takashi Fujita,Osamu Takeuchi,Shizuo Akira +10 more
TL;DR: It is shown by gene targeting that RIG-I is essential for induction of type I interferons (IFNs) after infection with RNA viruses in fibroblasts and conventional dendritic cells (DCs) and exert antiviral responses in a cell type-specific manner.
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Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling.
Masahiro Yamamoto,Shintaro Sato,Kiyotoshi Mori,Katsuaki Hoshino,Osamu Takeuchi,Kiyoshi Takeda,Shizuo Akira +6 more
TL;DR: Findings suggest that TRIF is involved in the TLR signaling, particularly in the MyD88-independent pathway.
Journal ArticleDOI
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
Masahiro Yamamoto,Shintaro Sato,Hiroaki Hemmi,Satoshi Uematsu,Katsuaki Hoshino,Tsuneyasu Kaisho,Osamu Takeuchi,Kiyoshi Takeda,Shizuo Akira +8 more
TL;DR: TRAM provides specificity for the MyD88-independent component of TLR4 signaling, and is identified as a fourth TIR domain–containing adaptor, TRIF-related adaptor molecule (TRAM), and analyzed its physiological function by gene targeting.