M
Masakazu Toi
Researcher at Kyoto University
Publications - 658
Citations - 28522
Masakazu Toi is an academic researcher from Kyoto University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 69, co-authored 578 publications receiving 23200 citations. Previous affiliations of Masakazu Toi include The Breast Cancer Research Foundation & Tokyo Metropolitan Komagome Hospital.
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Journal ArticleDOI
Evaluation of the Clinical Utility of the ICG Fluorescence Method Compared with the Radioisotope Method for Sentinel Lymph Node Biopsy in Breast Cancer
Tomoharu Sugie,Takayuki Kinoshita,Norikazu Masuda,Terumasa Sawada,Akira Yamauchi,Katsumasa Kuroi,Tetsuya Taguchi,Hiroko Bando,Hiroyasu Yamashiro,Tecchuu Lee,Nobuhiko Shinkura,Hironori Kato,Takafumi Ikeda,Kenichi Yoshimura,Hanae Ueyama,Masakazu Toi +15 more
TL;DR: The ICG fluorescence method may be an acceptable alternative to SLN detection using RI in breast cancer, and the combination of both methods achieved a significant improvement compared with RI alone.
Journal ArticleDOI
Cisplatin Induces the Proapoptotic Conformation of Bak in a ΔMEKK1-Dependent Manner
Aleksandra Mandic,Kristina Viktorsson,Magnus Molin,Göran Akusjärvi,Hidetaka Eguchi,Shin Ichi Hayashi,Masakazu Toi,Johan Hansson,Stig Linder,Maria C. Shoshan +9 more
TL;DR: Bak is identified as a cisplatin-regulated component downstream in a proapoptotic, JNK-independent ΔMEKK1 pathway and it is shown that reduction of Bak expression by antisense Bak reduced cisPlatin-induced loss of mitochondrial integrity and caspase cleavage activity in breast cancer cell lines.
Journal ArticleDOI
Extended adjuvant intermittent letrozole versus continuous letrozole in postmenopausal women with breast cancer (SOLE): a multicentre, open-label, randomised, phase 3 trial
Marco Colleoni,Weixiu Luo,Per Karlsson,Jacquie Chirgwin,Stefan Aebi,Guy Jerusalem,Patrick Neven,Erika Hitre,Marie-Pascale Graas,Edda Simoncini,Claus Kamby,Alastair M. Thompson,Sibylle Loibl,Joaquín Gavilá,Katsumasa Kuroi,Christian Marth,Bettina Müller,Seamus O'Reilly,Vincenzo Di Lauro,Andrea Gombos,Thomas Ruhstaller,Harold J. Burstein,Karin Ribi,Jürg Bernhard,Giuseppe Viale,Giuseppe Viale,Rudolf Maibach,Manuela Rabaglio-Poretti,Richard D. Gelber,Alan S. Coates,Angelo Di Leo,Meredith M. Regan,Aron Goldhirsch,An Vandebroek,Martine Berlière,Carine Mitine,Peter Vuylsteke,Marleen Borms,Randal D'hondt,Philippe Glorieux,Jeroen Mebis,Didier Verhoeven,Michael Coibion,Frederic Forget,Lionel Duck,Wim Wyendaele,Annelore Barbeaux,Jean-Paul Salmon,Patrick Berteloot,Joanna Vermeij,Vincent Richard,Saverio Cinieri,Lorenzo Gianni,Mario Clerico,Graziella Pinotti,Antonio Bernardo,Leo Biganzoli,Alessandra Gennari,Claudio Graiff,Dino Amadori,Rodolfo Passalacqua,John F. Forbes,Prudence A. Francis,Serene Foo,Frances M. Boyle,Andrew Redfern,Andre van der Westhuizen,Craig Lewis,Sharad Sharma,Philip Beale,Ian Byard,Stephen Begbie,Frank Sardelic,E Abdi,David G. Clark,Aaron Chindewere,Stephen Della-Fiorentina,Ray Asghari,Mohammed Islam,Lee Na Teo,Shane White,Linda Gilbert,Katherine Gardner,Catarina Uhlmann,Daniel Rauch,Meinrad Mannhart,Katharina Buser,Konstantin J. Dedes,Andreas Mueller,Christoph Rageth,Stephanie Von Orelli,Hans Joerg Senn,Olivia Pagani,Augusto Pedrazzini,Christoph Rochlitz,Alexandre Bodmer,Sandro Anchisi,Khalil Zaman,Roger von Moos,Daniel Betticher,Elena Kralidas,Razven Popescu,Mathias Fehr,Per Nyman,Anja Jungquist,Chaido Chamalidou,Theodoros Foukakis,Charlotta Dabrosin,Antonis Valachis,István Láng,Zsuzsanna Kahán,Javier Retamales,Ulloa Roberto Torres,Marcela Fritis,Sebastian Sole,Soledad Torres,Jaime Letzkus,Paula Escobar,Ines Vigneaux,Jorge Arancibia,Juana Bernardita Cardemil,Patricio Huidobro,Henry L. Gomez,Julie Wetter,Daniel A. Vorobiof,Gary McMichael,Justus Apffelstaedt,Igor Vorotnikov,Joel Schwartz,Thomas Openshaw,Hervé Bonnefoi,Jean-Philippe Jacquin,Natalie Bonichon-Lamichhane,Simona Borstner,Ashwini Budrukkar,Marianne Ewertz,Oscar Zambrano Quispe,Peter Michael Vestlev,Hella Danø,Ditte Nielsen,Erik Jakobsen,Inger Hoejris,Jurij Antonovic Bogovic,Britta Bjerregaard Jensen,Knud Aage Møller,Eric Lars Stenbygaard,Ravi Sharma,Carolyn Bedi,Maria Bews-Hair,Glyn Neades,Mike McKirdy,Matthew Barber,Abdulla Alhasso,Diana Ritchie,Judith Fraser,Lucy Scott,Frances Yuille,Alison Lannigan,Dermot Murphy,Mike Shere,Christian Jackisch,Oliver Tomé,Susanne Steer,Doris Augustin,Kristina Lübbe,Heike Köcker-Korus,Jörg-Uwe Deuker,Andrea Stefek,Marianne Just,Uwe Rhein,Christina Bechtner,Dirk-Toralf Baerens,Iris Schrader,Eva-Maria Grischke,Ralf Lorenz,Wolfgang Dietz,Jörg Thomalla,Jörg Schilling,Andreas Rempen,Heiko Graf,Gabriele Doering,Steffi Busch,Georg Heinrich,Hans Tesch,Christoph Uleer,Petra Krabisch,Siegfried Rösel,Christian Kurbacher,Horst Ostertag,Klaus-M Josten,Carsten Hielscher,Isolde Gröll,Ute Marie Mattner,Anita Prechtl,Tilmann Lantzsch,Eva Ciruelos,Isabel Garau,Meritxell Bellet,Miguel Angel Climent,Rafael López,Juan Antonio Virizuela,Begoña Bermejo,Noelia Martinez Janez,Kepa Amillano,Raúl Márquez,Joan Dorca,Maria Jose Godes,Santiago Gonzalez,Shinji Ohno,Tomoyuki Aruga,Daisuke Yotsumoto,Yutaka Yamamoto,Tomohiko Aihara,Takashi Morimoto,Hiroko Bando,Norikazu Masuda,Masakazu Toi,Kenjiro Aogi,Nobuaki Sato,Morihito Okada,Masato Takahashi,Eriko Tokunaga,Hiroji Iwata,Takashi Fujita,Michael Fridrik,Gunda Pristauz,Claudia Hackl,Christian F. Singer,Victor Wette,Michael Gnant,Josef Thaler,Richard Greil,Burghard Abendstein,Dietmar Heck,Diether Manfreda,Paul Sevelda,Irene Thiel,Frank Tuttlies,Herbert Stöger,Walter Neunteufel,John Crown,John Kennedy,Arnold Hill,John McCaffrey,Conleth G. Murphy,Linda E. Coate,Maccon M. Keane,Michael Martin,Miriam O'Connor,K. Duffy,Barbara Ruepp,Martine Piccart,Dimitrios Zardavas +252 more
TL;DR: Extended intermittent use of adjuvant letrozole in postmenopausal women with hormone receptor-positive, lymph node- positive, and operable breast cancer for which they had undergone local treatment and had completed 4-6 years of adjUvant endocrine therapy is hypothesised to improve breast cancer outcome compared with continuous use of letroZole.
Journal ArticleDOI
Phase III, randomized study of trastuzumab emtansine (T-DM1) {+/-} pertuzumab (P) vs trastuzumab + taxane (HT) for first-line treatment of HER2-positive MBC: Primary results from the MARIANNE study.
Paul Anthony Ellis,Carlos H. Barrios,Wolfgang Eiermann,Masakazu Toi,Young-Hyuck Im,Pierfranco Conte,Miguel Martin,Tadeusz Pienkowski,Xavier Pivot,Howard A. Burris,Alexander Strasak,Monika Patre,Edith A. Perez +12 more
TL;DR: Treatment with T-DM1 or with P + H + docetaxel or both has shown statistically significant increases in progression-free survival (PFS) and overall survival (OS) in phase II and III studies.
Journal ArticleDOI
Circulating cell-free DNA-based epigenetic assay can detect early breast cancer
Natsue Uehiro,Fumiaki Sato,Fengling Pu,Sunao Tanaka,Masahiro Kawashima,Kosuke Kawaguchi,Masahiro Sugimoto,Shigehira Saji,Shigehira Saji,Masakazu Toi +9 more
TL;DR: The authors' epigenetic-marker-based system distinguished BC patients from HVs with high accuracy, and as detection of early BC using this system was comparable with that of mammography screening, this system would be beneficial as an optional method of screening for BC.