T
Takashi Okauchi
Researcher at National Institute of Radiological Sciences
Publications - 63
Citations - 2550
Takashi Okauchi is an academic researcher from National Institute of Radiological Sciences. The author has contributed to research in topics: In vivo & Dopamine. The author has an hindex of 25, co-authored 62 publications receiving 2412 citations. Previous affiliations of Takashi Okauchi include Kyushu University.
Papers
More filters
Journal ArticleDOI
Longitudinal, Quantitative Assessment of Amyloid, Neuroinflammation, and Anti-Amyloid Treatment in a Living Mouse Model of Alzheimer's Disease Enabled by Positron Emission Tomography
Jun Maeda,Bin Ji,Toshiaki Irie,Takami Tomiyama,Masahiro Maruyama,Takashi Okauchi,Matthias Staufenbiel,Nobuhisa Iwata,Maiko Ono,Takaomi C. Saido,Kazutoshi Suzuki,Hiroshi Mori,Makoto Higuchi,Tetsuya Suhara +13 more
TL;DR: The results support the usefulness of the small animal-dedicated PET system in conjunction with high-specific radioactivity probes and appropriate Tg models not only for clarifying the mechanistic properties of amyloidogenesis in mouse models but also for preclinical tests of emerging diagnostic and therapeutic approaches to AD.
Journal ArticleDOI
Functional brain mapping of monkey tool use.
Shigeru Obayashi,Shigeru Obayashi,Shigeru Obayashi,Tetsuya Suhara,Koichi Kawabe,Takashi Okauchi,Jun Maeda,Yoshihide Akine,Hirotaka Onoe,Atsushi Iriki +9 more
TL;DR: In this article, the authors explored tool use-induced activation within the intraparietal area and elsewhere in the alert monkey brain using positron emission tomography (PET) and found a significant increase in cerebral blood flow in corresponding intra-parietal region, basal ganglia, presupplementary motor area, premotor cortex, and cerebellum.
Journal ArticleDOI
Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies.
Bin Ji,Jun Maeda,Makoto Sawada,Maiko Ono,Takashi Okauchi,Motoki Inaji,Ming-Rong Zhang,Kazutoshi Suzuki,Kiyoshi Ando,Matthias Staufenbiel,John Q. Trojanowski,Virginia M.-Y. Lee,Makoto Higuchi,Tetsuya Suhara +13 more
TL;DR: Together, PBR expressions in astrocytes and microglia reflect beneficial and deleterious glial reactions, respectively, in diverse neurodegenerative disorders including AD, pointing to new applications of PBR imaging for monitoring the impact of gliosis on the pathogenesis and treatment of AD.
Journal ArticleDOI
Novel peripheral benzodiazepine receptor ligand [11C]DAA1106 for PET: an imaging tool for glial cells in the brain.
Jun Maeda,Tetsuya Suhara,Ming-Rong Zhang,Takashi Okauchi,Fumihiko Yasuno,Yoko Ikoma,Motoki Inaji,Yuji Nagai,Akihiro Takano,Shigeru Obayashi,Kazutoshi Suzuki +10 more
TL;DR: Results indicated that [11C]DAA1106 might be a good ligand for in vivo imaging of PBR, based on its in vivo properties in rat and monkey brain.
Journal ArticleDOI
Development of a new radioligand, N-(5-fluoro-2-phenoxyphenyl)-N-(2-[18F]fluoroethyl-5-methoxybenzyl)acetamide, for pet imaging of peripheral benzodiazepine receptor in primate brain.
Ming-Rong Zhang,Jun Maeda,Masanao Ogawa,Junko Noguchi,Takehito Ito,Yuichiro Yoshida,Takashi Okauchi,Shigeru Obayashi,Tetsuya Suhara,Kazutoshi Suzuki +9 more
TL;DR: The biological data indicate that [(18)F]5 is a useful PET ligand for PBR and is currently used for imaging PBR in human brain.