M
Masataka Sugimoto
Researcher at Nagoya University
Publications - 37
Citations - 2314
Masataka Sugimoto is an academic researcher from Nagoya University. The author has contributed to research in topics: Senescence & Small hairpin RNA. The author has an hindex of 17, co-authored 36 publications receiving 2053 citations. Previous affiliations of Masataka Sugimoto include University of Tsukuba & St. Jude Children's Research Hospital.
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Journal ArticleDOI
Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence.
Naoko Ohtani,Zoe Zebedee,Thomas J. G. Huot,Julie A. Stinson,Masataka Sugimoto,Yasuhiro Ohashi,Andrew D. Sharrocks,Gordon Peters,Eiji Hara +8 more
TL;DR: A role is demonstrated for the Ets1 and Ets2 transcription factors based on their ability to activate the p16INK4a promoter through an ETS-binding site and their patterns of expression during the lifespan of human diploid fibroblasts.
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Physical and Functional Interactions of the Arf Tumor Suppressor Protein with Nucleophosmin/B23.
TL;DR: Using tandem-affinity-tagged p19Arf, Arf-associated proteins from mouse NIH 3T3 fibroblasts undergoing cell cycle arrest were purified and linked to nucleolar and ribosomal proteins, including nucleophosmin/B23 (NPM), a protein thought to foster the maturation of preribosomal particles.
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Nucleolar Arf Tumor Suppressor Inhibits Ribosomal RNA Processing
TL;DR: It is shown that p19(Arf) inhibits production of ribosomal RNA, retarding processing of 47/45S and 32S precursors and preventing the proliferation of cells lacking Mdm2 and p53, albeit less efficiently.
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Senolysis by glutaminolysis inhibition ameliorates various age-associated disorders.
Yoshikazu Johmura,Takehiro Yamanaka,Satotaka Omori,Teh Wei Wang,Yuki Sugiura,Masaki Matsumoto,Narumi Suzuki,Soichiro Kumamoto,Kiyoshi Yamaguchi,Seira Hatakeyama,Tomoyo Takami,Rui Yamaguchi,Eigo Shimizu,Kazutaka Ikeda,Nobuyuki Okahashi,Ryuta Mikawa,Makoto Suematsu,Makoto Arita,Masataka Sugimoto,Keiichi I. Nakayama,Yoichi Furukawa,Seiya Imoto,Makoto Nakanishi +22 more
TL;DR: In this article, the authors identified glutaminase 1 (GLS1) as an essential gene for the survival of human senescent cells and showed that inhibition of GLS1-dependent glutaminolysis in aged mice eliminated the cells specifically and ameliorated age-associated organ dysfunction.
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Elimination of p19 ARF -expressing cells enhances pulmonary function in mice
Michihiro Hashimoto,Azusa Asai,Hiroyuki Kawagishi,Ryuta Mikawa,Yuji Iwashita,Kazuki Kanayama,Kazushi Sugimoto,Tadashi Sato,Mitsuo Maruyama,Masataka Sugimoto +9 more
TL;DR: It is demonstrated that pulmonary function in 12-month-old mice was reversibly restored by the elimination of p19ARF-expressing cells, indicating that the aging-associated decline in lung function was, at least partly, attributed to p19arF and was recovered by eliminating p19 ARF- expressing cells.