K
Kengo Homma
Researcher at University of Tokyo
Publications - 15
Citations - 803
Kengo Homma is an academic researcher from University of Tokyo. The author has contributed to research in topics: SOD1 & Amyotrophic lateral sclerosis. The author has an hindex of 9, co-authored 15 publications receiving 670 citations. Previous affiliations of Kengo Homma include Tokyo Medical and Dental University.
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Journal ArticleDOI
The Src/c-Abl pathway is a potential therapeutic target in amyotrophic lateral sclerosis.
Keiko Imamura,Yuishin Izumi,Akira Watanabe,Kayoko Tsukita,Knut Woltjen,Takuya Yamamoto,Akitsu Hotta,Akitsu Hotta,Takayuki Kondo,Shiho Kitaoka,Akira Ohta,Akito Tanaka,Dai Watanabe,Mitsuya Morita,Hiroshi Takuma,Akira Tamaoka,Tilo Kunath,Selina Wray,Hirokazu Furuya,Takumi Era,Kouki Makioka,Koichi Okamoto,Takao Fujisawa,Hideki Nishitoh,Kengo Homma,Hidenori Ichijo,Jean-Pierre Julien,Nanako Obata,Masato Hosokawa,Haruhiko Akiyama,Satoshi Kaneko,Takashi Ayaki,Hidefumi Ito,Ryuji Kaji,Ryosuke Takahashi,Shinya Yamanaka,Haruhisa Inoue +36 more
TL;DR: Analysis of ALS patient iPSC-derived motor neurons indicates that Src/c-Abl inhibitors may have potential for treating ALS, and a phenotypic screen to repurpose existing drugs using ALS motor neuron survival as readout shows that inhibitors of Src or c-ABL kinases promoted autophagy and rescued ALS motor neurons from degeneration.
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Ubiquitin-like Sequence in ASK1 Plays Critical Roles in the Recognition and Stabilization by USP9X and Oxidative Stress-Induced Cell Death
Hiroaki Nagai,Takuya Noguchi,Kengo Homma,Kazumi Katagiri,Kohsuke Takeda,Atsushi Matsuzawa,Hidenori Ichijo +6 more
TL;DR: The identification of the deubiquitinating enzyme USP9X as a binding partner of ASK1 that mediates oxidative stress-induced cell death through activation of the JNK and p38 MAPK pathways is identified and results demonstrate that USP 9X-dependent stabilization of activated ASK 1 plays a crucial role in oxidative Stress- induced cell death.
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SOD1 as a Molecular Switch for Initiating the Homeostatic ER Stress Response under Zinc Deficiency
Kengo Homma,Takao Fujisawa,Naomi Tsuburaya,Namiko Yamaguchi,Hisae Kadowaki,Kohsuke Takeda,Hideki Nishitoh,Atsushi Matsuzawa,Isao Naguro,Hidenori Ichijo +9 more
TL;DR: It is found that SOD1 has a function as a molecular switch that activates the ER stress response, which plays an important role in cellular homeostasis under zinc-deficient conditions.
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SOD1 in neurotoxicity and its controversial roles in SOD1 mutation-negative ALS
TL;DR: The toxic mechanisms of mutant SOD1 (SOD1(mut)) and misfolded S OD1(WT) in the context of ALS as well as the potential implication of these mechanisms in SOD 1 mutation-negative ALS are discussed.
Journal ArticleDOI
Purification, characterization, and cDNA cloning of procathepsin L from the culture medium of NIH-Sape-4, an embryonic cell line of Sarcophaga peregrina (flesh fly), and its involvement in the differentiation of imaginal discs.
TL;DR: Northern blotting analysis revealed that unfertilized eggs contain a significant amount of mRNA for the procathepsin L as a maternal mRNA, suggesting that procat hepsins L is an essential proteinase for differentiation of imaginal discs.