M
Masato Suzuki
Researcher at National Institutes of Health
Publications - 157
Citations - 4165
Masato Suzuki is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Plasmid & Medicine. The author has an hindex of 33, co-authored 134 publications receiving 3567 citations. Previous affiliations of Masato Suzuki include Harvard University & University of Tokyo.
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Journal ArticleDOI
Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation
Masato Suzuki,Hitomi Mimuro,Kotaro Kiga,Makoto Fukumatsu,Nozomi Ishijima,Hanako Morikawa,Shigenori Nagai,Shigeo Koyasu,Robert H. Gilman,Dangeruta Kersulyte,Douglas E. Berg,Chihiro Sasakawa +11 more
TL;DR: It is reported that a conserved motif in the C-terminal region of CagA, which is distinct from the EPIYA motifs used for phosphorylation and which is designated CRPIA, plays pivotal roles in Hp pathogenesis.
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Interaction of CagA with Crk plays an important role in Helicobacter pylori–induced loss of gastric epithelial cell adhesion
TL;DR: In this article, the authors show that the phosphorylated CagA binds Crk adaptor proteins (Crk-II, Crk-I, and Crk -L) and that the interaction is important for the CAGA-mediated host responses during H. pylori infection.
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Catalytic Enantioselective Strecker Reaction of Ketoimines
TL;DR: The reaction has a broad substrate generality, giving high enantioselectivity from aromatic, ethyl, primary alkyl, and alpha,beta-unsaturated ketoimines, and could be easily converted to disubstituted alpha-amino acids and their derivatives.
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Helicobacter pylori Dampens Gut Epithelial Self-Renewal by Inhibiting Apoptosis, a Bacterial Strategy to Enhance Colonization of the Stomach
Hitomi Mimuro,Toshihiko Suzuki,Shigenori Nagai,Gabriele Rieder,Masato Suzuki,Takeshi Nagai,Yukihiro Fujita,Kanna Nagamatsu,Nozomi Ishijima,Shigeo Koyasu,Rainer Haas,Chihiro Sasakawa +11 more
TL;DR: CagA activates host cell survival and antiapoptotic pathways to overcome self-renewal of the gastric epithelium and help sustain Hp infection.
Journal ArticleDOI
BabA-mediated Adherence Is a Potentiator of the Helicobacter pylori Type IV Secretion System Activity
Nozomi Ishijima,Masato Suzuki,Hiroshi Ashida,Yusuke Ichikawa,Yumi Kanegae,Izumu Saito,Thomas Borén,Rainer Haas,Chihiro Sasakawa,Hitomi Mimuro +9 more
TL;DR: H. pylori can exploit BabA-Leb binding to trigger TFSS-dependent host cell signaling to induce the transcription of genes that enhance inflammation, development of intestinal metaplasia, and associated precancerous transformations.