M
Matteo Berti
Researcher at University of Zurich
Publications - 17
Citations - 2185
Matteo Berti is an academic researcher from University of Zurich. The author has contributed to research in topics: DNA replication & Homologous recombination. The author has an hindex of 13, co-authored 17 publications receiving 1681 citations. Previous affiliations of Matteo Berti include International Centre for Genetic Engineering and Biotechnology & Saint Louis University.
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Journal ArticleDOI
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
Ralph Zellweger,Damian Dalcher,Karun Mutreja,Matteo Berti,Jonas A. Schmid,Raquel Herrador,Alessandro Vindigni,Massimo Lopes +7 more
TL;DR: Genotoxic treatments in human cells consistently induce uncoupling of replication forks and their remodeling into four-way junctions by the RAD51 recombinase.
Journal ArticleDOI
Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition
Matteo Berti,Arnab Ray Chaudhuri,Saravanabhavan Thangavel,Shivasankari Gomathinayagam,Saša Kenig,Marko Vujanovic,Federico Odreman,Timo Glatter,Timo Glatter,Simona Graziano,Ramiro Mendoza-Maldonado,Francesca Marino,Bojana Lucic,Valentina Biasin,Matthias Gstaiger,Matthias Gstaiger,Ruedi Aebersold,Ruedi Aebersold,Ruedi Aebersold,Julia M. Sidorova,Raymond J. Monnat,Massimo Lopes,Alessandro Vindigni +22 more
TL;DR: It is shown that the poly(ADP-ribosyl)ation activity of PARP1 stabilizes forks in the regressed state by limiting their restart by RECQ1, and offers molecular perspectives to potentiate chemotherapeutic regimens based on TOP1 inhibition.
Journal ArticleDOI
DNA2 drives processing and restart of reversed replication forks in human cells
Saravanabhavan Thangavel,Matteo Berti,Maryna Levikova,Cosimo Pinto,Shivasankari Gomathinayagam,Marko Vujanovic,Ralph Zellweger,Hayley R. Moore,Eu Han Lee,Eric A. Hendrickson,Petr Cejka,Sheila A. Stewart,Massimo Lopes,Alessandro Vindigni +13 more
TL;DR: Following prolonged genotoxic stress, DNA2 and WRN functionally interact to degrade reversed replication forks and promote replication restart, thereby preventing aberrant processing of unresolved replication intermediates.
Journal ArticleDOI
Replication Fork Reversal Triggers Fork Degradation in BRCA2-defective Cells
Sofija Mijic,Ralph Zellweger,Nagaraja Chappidi,Matteo Berti,Kurt Jacobs,Karun Mutreja,Sebastian Ursich,Arnab Ray Chaudhuri,Arnab Ray Chaudhuri,André Nussenzweig,Pavel Janscak,Massimo Lopes +11 more
TL;DR: It is proposed that BRCA2 is dispensable for RAD51-mediated fork reversal, but assembles stable RAD51 nucleofilaments on regressed arms, to protect them from degradation, and revealed how HR factors cooperate in fork remodeling.
Journal ArticleDOI
Replication stress: getting back on track.
TL;DR: The emerging mechanisms of the replication-stress response in mammalian cells are reviewed and how they may influence the dynamics of the core DNA replication complex is considered.