M
Matthew J. Marton
Researcher at National Institutes of Health
Publications - 25
Citations - 18056
Matthew J. Marton is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Gene & DNA microarray. The author has an hindex of 17, co-authored 23 publications receiving 17472 citations. Previous affiliations of Matthew J. Marton include Agilent Technologies.
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Journal ArticleDOI
Gene expression profiling predicts clinical outcome of breast cancer
Laura J. van't Veer,Hongyue Dai,Marc J. van de Vijver,Yudong D. He,Augustinus A. M. Hart,Mao Mao,Hans Peterse,Karin van der Kooy,Matthew J. Marton,Anke T. Witteveen,George J. Schreiber,Ron M. Kerkhoven,Christopher J. Roberts,Peter S. Linsley,René Bernards,Stephen H. Friend +15 more
TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.
Journal ArticleDOI
Functional Discovery via a Compendium of Expression Profiles
Timothy P. Hughes,Matthew J. Marton,Allan R. Jones,Christopher J. Roberts,Roland Stoughton,Christopher D. Armour,Holly A. Bennett,Ernest M. Coffey,Hongyue Dai,Yudong D. He,Matthew J. Kidd,Amy M King,Michael R. Meyer,David J. Slade,Pek Yee Lum,Sergey B. Stepaniants,Daniel D. Shoemaker,Daniel J Gachotte,Kalpana Chakraburtty,Julian A. Simon,Martin Bard,Stephen H. Friend +21 more
TL;DR: A reference database or "compendium" of expression profiles corresponding to 300 diverse mutations and chemical treatments in S. cerevisiae is constructed, and it is shown that the cellular pathways affected can be determined by pattern matching, even among very subtle profiles.
Journal ArticleDOI
Expression profiling using microarrays fabricated by an ink-jet oligonucleotide synthesizer.
Timothy P. Hughes,Mao Mao,Allan R. Jones,Julja Burchard,Matthew J. Marton,Karen W. Shannon,Steven M. Lefkowitz,Michael Ziman,Janell M. Schelter,Michael R. Meyer,Sumire Kobayashi,Colleen P. Davis,Hongyue Dai,Yudong D. He,Sergey B. Stephaniants,Guy Cavet,Wynn L. Walker,Anne E. West,Ernest M. Coffey,Daniel D. Shoemaker,Roland Stoughton,Alan P. Blanchard,Stephen H. Friend,Peter S. Linsley +23 more
TL;DR: It is found that 60-mer oligonucleotides reliably detect transcript ratios at one copy per cell in complex biological samples, and that ink-jet arrays are compatible with several different sample amplification and labeling techniques.
Journal ArticleDOI
Signaling and Circuitry of Multiple MAPK Pathways Revealed by a Matrix of Global Gene Expression Profiles
Christopher J. Roberts,Bryce Nelson,Matthew J. Marton,Roland Stoughton,Michael R. Meyer,Holly A. Bennett,Yudong D. He,Hongyue Dai,Wynn L. Walker,Timothy P. Hughes,Mike Tyers,Charles Boone,Stephen H. Friend +12 more
TL;DR: Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response and global transcript analysis reflects biological responses associated with the activation and perturbation of signalTransduction pathways.
Journal ArticleDOI
Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast
Krishnamurthy Natarajan,Michael R. Meyer,Belinda M. Jackson,David J. Slade,Christopher J. Roberts,Alan G. Hinnebusch,Matthew J. Marton +6 more
TL;DR: The broad transcriptional response evoked by Gcn4p is produced by diverse stress conditions, and numerous genes encoding protein kinases and transcription factors were identified as targets, suggesting that Gcn 4p is a master regulator of gene expression.