Matthew J. Marton

TL;DR: DNA microarray analysis on primary breast tumours of 117 young patients is used and supervised classification is applied to identify a gene expression signature strongly predictive of a short interval to distant metastases (‘poor prognosis’ signature) in patients without tumour cells in local lymph nodes at diagnosis, providing a strategy to select patients who would benefit from adjuvant therapy.

TL;DR: A reference database or "compendium" of expression profiles corresponding to 300 diverse mutations and chemical treatments in S. cerevisiae is constructed, and it is shown that the cellular pathways affected can be determined by pattern matching, even among very subtle profiles.

TL;DR: It is found that 60-mer oligonucleotides reliably detect transcript ratios at one copy per cell in complex biological samples, and that ink-jet arrays are compatible with several different sample amplification and labeling techniques.

TL;DR: Genome-wide transcript profiling was used to monitor signal transduction during yeast pheromone response and global transcript analysis reflects biological responses associated with the activation and perturbation of signalTransduction pathways.

TL;DR: The broad transcriptional response evoked by Gcn4p is produced by diverse stress conditions, and numerous genes encoding protein kinases and transcription factors were identified as targets, suggesting that Gcn 4p is a master regulator of gene expression.