R
Rachid Drissi
Researcher at Cincinnati Children's Hospital Medical Center
Publications - 52
Citations - 3509
Rachid Drissi is an academic researcher from Cincinnati Children's Hospital Medical Center. The author has contributed to research in topics: Medicine & Cancer research. The author has an hindex of 17, co-authored 36 publications receiving 2689 citations. Previous affiliations of Rachid Drissi include University of Cincinnati Academic Health Center & Ohio State University.
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Journal ArticleDOI
Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma.
Dominik Sturm,Hendrik Witt,Hendrik Witt,Volker Hovestadt,Dong Anh Khuong-Quang,David T.W. Jones,Carolin Konermann,Elke Pfaff,Martje Tönjes,Martin Sill,Sebastian Bender,Marcel Kool,Marc Zapatka,Natalia Becker,Manuela Zucknick,Thomas Hielscher,Xiaoyang Liu,Adam M. Fontebasso,Marina Ryzhova,Steffen Albrecht,Karine Jacob,Marietta Wolter,Martin Ebinger,Martin U. Schuhmann,Timothy E. Van Meter,Michael C. Frühwald,Holger Hauch,Arnulf Pekrun,Bernhard Radlwimmer,Tim Niehues,Gregor Von Komorowski,Matthias Dürken,Andreas E. Kulozik,Jenny Madden,Andrew M. Donson,Nicholas K. Foreman,Rachid Drissi,Maryam Fouladi,Wolfram Scheurlen,Andreas von Deimling,Andreas von Deimling,Camelia M. Monoranu,Wolfgang Roggendorf,Christel Herold-Mende,Andreas Unterberg,Christof M. Kramm,Jörg Felsberg,Christian Hartmann,Benedikt Wiestler,Wolfgang Wick,Till Milde,Till Milde,Olaf Witt,Olaf Witt,Anders Lindroth,Jeremy Schwartzentruber,Damien Faury,Adam Fleming,Magdalena Zakrzewska,Pawel P. Liberski,Krzysztof Zakrzewski,Peter Hauser,Miklós Garami,Almos Klekner,László Bognár,Sorana Morrissy,Florence M.G. Cavalli,Michael D. Taylor,Peter van Sluis,Jan Koster,Rogier Versteeg,Richard Volckmann,Tom Mikkelsen,Kenneth Aldape,Guido Reifenberger,V. Peter Collins,Jacek Majewski,Andrey Korshunov,Peter Lichter,Christoph Plass,Nada Jabado,Stefan M. Pfister,Stefan M. Pfister +82 more
TL;DR: It is demonstrated that each H3F3A mutation defines an epigenetic subgroup of GBM with a distinct global methylation pattern, and that they are mutually exclusive with IDH1 mutations, which characterize a third mutation-defined subgroup.
Journal ArticleDOI
New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs
Dominik Sturm,Dominik Sturm,Brent A. Orr,Umut H. Toprak,Volker Hovestadt,David T.W. Jones,David Capper,David Capper,Martin Sill,Ivo Buchhalter,Paul A. Northcott,Irina Leis,Marina Ryzhova,Christian Koelsche,Christian Koelsche,Elke Pfaff,Elke Pfaff,Sariah Allen,Gnanaprakash Balasubramanian,Barbara C. Worst,Barbara C. Worst,Kristian W. Pajtler,Sebastian Brabetz,Pascal Johann,Pascal Johann,Felix Sahm,Felix Sahm,Jüri Reimand,Jüri Reimand,Alan Mackay,Diana Carvalho,Marc Remke,Joanna J. Phillips,Arie Perry,Cynthia Cowdrey,Rachid Drissi,Maryam Fouladi,Felice Giangaspero,Maria Łastowska,Wiesława Grajkowska,Wolfram Scheurlen,Torsten Pietsch,Christian Hagel,Johannes Gojo,Daniela Lötsch,Walter Berger,Irene Slavc,Christine Haberler,Anne Jouvet,Stefan Holm,Silvia Hofer,Marco Prinz,Catherine Keohane,Iris Fried,Christian Mawrin,David Scheie,Bret C. Mobley,Matthew Schniederjan,Mariarita Santi,Anna Maria Buccoliero,Sonika Dahiya,Christof M. Kramm,André O. von Bueren,Katja von Hoff,Stefan Rutkowski,Christel Herold-Mende,Michael C. Frühwald,Till Milde,Till Milde,Martin Hasselblatt,Pieter Wesseling,Pieter Wesseling,Jochen Rößler,Ulrich Schüller,Martin Ebinger,Jens Schittenhelm,Stephan Frank,Rainer Grobholz,Istvan Vajtai,Volkmar Hans,Reinhard Schneppenheim,Karel Zitterbart,V. Peter Collins,Eleonora Aronica,Pascale Varlet,Stéphanie Puget,Christelle Dufour,Jacques Grill,Dominique Figarella-Branger,Marietta Wolter,Martin U. Schuhmann,Tarek Shalaby,Michael A. Grotzer,Timothy E. Van Meter,Camelia M. Monoranu,Jörg Felsberg,Guido Reifenberger,Matija Snuderl,Lynn Ann Forrester,Jan Koster,Rogier Versteeg,Richard Volckmann,Peter van Sluis,Stephan Wolf,Tom Mikkelsen,Amar Gajjar,Kenneth Aldape,Andrew S. Moore,Michael D. Taylor,Chris Jones,Nada Jabado,Matthias A. Karajannis,Roland Eils,Matthias Schlesner,Peter Lichter,Andreas von Deimling,Andreas von Deimling,Stefan M. Pfister,Stefan M. Pfister,David W. Ellison,Andrey Korshunov,Andrey Korshunov,Marcel Kool +122 more
TL;DR: It is demonstrated that a significant proportion of institutionally diagnosed CNS-PNETs display molecular profiles indistinguishable from those of various other well-defined CNS tumor entities, facilitating diagnosis and appropriate therapy for patients with these tumors.
Journal ArticleDOI
Clinical, Radiologic, Pathologic, and Molecular Characteristics of Long-Term Survivors of Diffuse Intrinsic Pontine Glioma (DIPG): A Collaborative Report From the International and European Society for Pediatric Oncology DIPG Registries.
Lindsey M. Hoffman,Sophie E. M. Veldhuijzen van Zanten,Niclas Colditz,Joshua J Baugh,Brooklyn Chaney,Marion Hoffmann,Marion Hoffmann,Adam Lane,Christine Fuller,Lili Miles,Cynthia Hawkins,Ute Bartels,Eric Bouffet,Stewart Goldman,Sarah Leary,Nicholas K. Foreman,Roger J. Packer,Katherine E. Warren,Alberto Broniscer,Mark W. Kieran,Jane E. Minturn,Melanie Comito,Emmett Broxson,Chie Schin Shih,Soumen Khatua,Murali Chintagumpala,Anne Sophie Carret,Nancy Yanez Escorza,Tim Hassall,David S. Ziegler,David S. Ziegler,Nicholas G. Gottardo,Hetal Dholaria,Renee Doughman,Martin Benesch,Rachid Drissi,Javad Nazarian,Nada Jabado,Nathalie Boddaert,Pascale Varlet,Géraldine Giraud,Géraldine Giraud,David Castel,Stéphanie Puget,Chris Jones,Esther Hulleman,Piergiorgio Modena,Marzia Giagnacovo,Manila Antonelli,Torsten Pietsch,Gerrit H. Gielen,David T.W. Jones,Dominik Sturm,Dominik Sturm,Stefan M. Pfister,Stefan M. Pfister,Nicolas U. Gerber,Michael A. Grotzer,Elke Pfaff,Elke Pfaff,André O. von Bueren,Darren Hargrave,Guirish A. Solanki,Filip Jadrijevic Cvrlje,Gertjan J.L. Kaspers,Gertjan J.L. Kaspers,William P. Vandertop,Jacques Grill,Simon Bailey,Veronica Biassoni,Maura Massimino,Raphael Calmon,Esther Sanchez,Brigitte Bison,Monika Warmuth-Metz,James L. Leach,Blaise V. Jones,Dannis G. van Vuurden,Christof M. Kramm,Maryam Fouladi +79 more
TL;DR: Clinical, radiologic, and molecular factors that correlate with survival in children and young adults with DIPG are reported, which are important for risk stratification in future clinical trials.
Journal ArticleDOI
Spatial genomic heterogeneity in diffuse intrinsic pontine and midline high-grade glioma: implications for diagnostic biopsy and targeted therapeutics
Lindsey M. Hoffman,Mariko DeWire,Scott Ryall,Pawel Buczkowicz,James L. Leach,Lili Miles,Arun K. Ramani,Michael Brudno,Shiva Senthil Kumar,Rachid Drissi,Phillip J. Dexheimer,Ralph Salloum,Lionel M.L. Chow,Trent R. Hummel,Charles B. Stevenson,Q. Richard Lu,Blaise V. Jones,David P. Witte,Bruce J. Aronow,Cynthia Hawkins,Maryam Fouladi +20 more
TL;DR: Spatial conservation of prognostically-relevant and therapeutically-targetable somatic mutations in DIPG and mHGG contrasts the significant heterogeneity of driver mutations seen in adult HGG and supports uniform implementation of diagnostic biopsy in DISPs to classify molecular risk groups and guide therapeutic strategy.
Journal ArticleDOI
Olig2-Dependent Reciprocal Shift in PDGF and EGF Receptor Signaling Regulates Tumor Phenotype and Mitotic Growth in Malignant Glioma
Fanghui Lu,Fanghui Lu,Ying Chen,Chuntao Zhao,Haibo Wang,Danyang He,Lingli Xu,Jincheng Wang,Xuelian He,Yaqi Deng,Ellen E. Lu,Xue Liu,Ravinder Verma,Hong Bu,Rachid Drissi,Maryam Fouladi,Anat Stemmer-Rachamimov,Dennis K. Burns,Mei Xin,Joshua B. Rubin,El Mustapha Bahassi,Peter Canoll,Eric C. Holland,Q. Richard Lu,Q. Richard Lu +24 more
TL;DR: Genome occupancy and expression profiling analyses reveal that Olig2 directly activates cell-proliferation machinery to promote tumorigenesis and drives mitotic growth and regulates glioma phenotypic plasticity.