M
Matthias Elstner
Researcher at Technische Universität München
Publications - 40
Citations - 1797
Matthias Elstner is an academic researcher from Technische Universität München. The author has contributed to research in topics: Mitochondrial DNA & Neurodegeneration. The author has an hindex of 21, co-authored 38 publications receiving 1599 citations. Previous affiliations of Matthias Elstner include Ludwig Maximilian University of Munich & Newcastle University.
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Journal ArticleDOI
Individual dopaminergic neurons show raised iron levels in Parkinson disease.
Arthur E. Oakley,Joanna F. Collingwood,Jon Dobson,G. Love,H. R. Perrott,James A. Edwardson,Matthias Elstner,Christopher Morris +7 more
TL;DR: Raised intraneuronal iron was identified in single defined substantia nigra neurons in PD but not in other movement disorders such as Huntington disease.
Journal ArticleDOI
Absence of an Orphan Mitochondrial Protein, C19orf12, Causes a Distinct Clinical Subtype of Neurodegeneration with Brain Iron Accumulation
Monika Hartig,Arcangela Iuso,Tobias B. Haack,Tomasz Kmieć,Elżbieta Jurkiewicz,Katharina Heim,Sigrun Roeber,Victoria Tarabin,Sabrina Dusi,Małgorzata Krajewska-Walasek,Sergiusz Jozwiak,Maja Hempel,Juliane Winkelmann,Matthias Elstner,Konrad Oexle,Thomas Klopstock,W. Mueller-Felber,Thomas Gasser,Claudia Trenkwalder,Valeria Tiranti,Hans A. Kretzschmar,Gerd Schmitz,Tim M. Strom,Thomas Meitinger,Holger Prokisch +24 more
TL;DR: The mitochondrial localization together with the immunohistopathological findings suggests a pathomechanistic overlap with common forms of neurodegenerative disorders.
Journal ArticleDOI
Creatine supplementation in Parkinson disease: a placebo-controlled randomized pilot trial.
Andreas Bender,W. Koch,Matthias Elstner,Y. Schombacher,Julia Bender,M. Moeschl,F. Gekeler,Bertram Müller-Myhsok,T. Gasser,Klaus Tatsch,Thomas Klopstock +10 more
TL;DR: Creatine improved patient mood and led to a smaller dose increase of dopaminergic therapy but had no effect on overall Unified Parkinson's Disease Rating Scale scores or dopamine transporter SPECT.
Journal ArticleDOI
Expression analysis of dopaminergic neurons in Parkinson's disease and aging links transcriptional dysregulation of energy metabolism to cell death
Matthias Elstner,Matthias Elstner,Christopher Morris,Katharina Heim,Andreas Bender,Divya Mehta,Evelyn Jaros,Thomas Klopstock,Thomas Meitinger,Thomas Meitinger,Douglass M. Turnbull,Holger Prokisch,Holger Prokisch +12 more
TL;DR: In this article, the authors used a laser capture microdissection to isolate dopamine neurons from the substantia nigra pars compacta of PD patients, age-matched and young controls to determine transcriptional changes by expression profiling and pathway analysis.
Journal ArticleDOI
TOM40 mediates mitochondrial dysfunction induced by α-synuclein accumulation in Parkinson's disease.
Andreas Bender,Andreas Bender,Paula Desplats,Brian Spencer,Edward Rockenstein,Anthony Adame,Matthias Elstner,Christoph Laub,Sarina K. Mueller,Andrew O. Koob,Michael Mante,Emily Pham,Thomas Klopstock,Eliezer Masliah +13 more
TL;DR: It is reported here that TOM40 is significantly reduced in the brain of PD patients and in α-Syn transgenic mice, and alterations in the mitochondrial protein transport machinery might contribute to mitochondrial impairment inα-Synucleinopathies.