M
Małgorzata Krajewska-Walasek
Researcher at Memorial Hospital of South Bend
Publications - 119
Citations - 3944
Małgorzata Krajewska-Walasek is an academic researcher from Memorial Hospital of South Bend. The author has contributed to research in topics: Exome sequencing & Nijmegen breakage syndrome. The author has an hindex of 25, co-authored 118 publications receiving 3396 citations.
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Journal ArticleDOI
Expert consensus document: Clinical and molecular diagnosis, screening and management of Beckwith-Wiedemann syndrome: an international consensus statement.
Frédéric Brioude,Jennifer M. Kalish,Alessandro Mussa,Alison Foster,Alison Foster,Jet Bliek,Giovanni Battista Ferrero,Susanne E Boonen,Trevor Cole,Robert Baker,Monica Bertoletti,Guido Cocchi,Carole Coze,Maurizio De Pellegrin,Khalid Hussain,Abdulla Ibrahim,Mark D. Kilby,Mark D. Kilby,Małgorzata Krajewska-Walasek,Christian P. Kratz,Edmund J. Ladusans,Pablo Lapunzina,Yves Le Bouc,Saskia M. Maas,Fiona Macdonald,Katrin Õunap,Licia Peruzzi,Sylvie Rossignol,Silvia Russo,Caroleen Shipster,Agata Skórka,Katrina Tatton-Brown,Jair Tenorio,Chiara Tortora,Karen Grønskov,Irène Netchine,Raoul C.M. Hennekam,Dirk Prawitt,Zeynep Tümer,Thomas Eggermann,Deborah J G Mackay,Andrea Riccio,Eamonn R. Maher +42 more
TL;DR: An international consensus group agreed upon 72 recommendations for the clinical and molecular diagnosis and management of Beckwith–Wiedemann syndrome, including comprehensive protocols for the molecular investigation, care and treatment of patients from the prenatal period to adulthood.
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Imprinting-Mutation Mechanisms in Prader-Willi Syndrome
T. Ohta,Todd A. Gray,Peter K. Rogan,Karin Buiting,J. M. Gabriel,Shinji Saitoh,B. Muralidhar,B. Bilienska,Małgorzata Krajewska-Walasek,Daniel J. Driscoll,Bernhard Horsthemke,Merlin G. Butler,Robert D. Nicholls +12 more
TL;DR: It is suggested that promoter elements at SNRPN play a key role in the initiation of imprint switching during spermatogenesis, since the epigenetic effect of an IM in the parental germ line determines the phenotypic effect in the patient.
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Heterozygous missense mutations in SMARCA2 cause Nicolaides-Baraitser syndrome
Jeroen Van Houdt,Beata Nowakowska,Sérgio B. Sousa,Sérgio B. Sousa,Barbera D. C. van Schaik,Eve Seuntjens,Nelson Avonce,Alejandro Sifrim,Omar A. Abdul-Rahman,Marie José H. Van Den Boogaard,Armand Bottani,Marco Castori,Valérie Cormier-Daire,Matthew A. Deardorff,Isabel Filges,Alan Fryer,Jean Pierre Fryns,Simone Gana,Livia Garavelli,Gabriele Gillessen-Kaesbach,Bryan D. Hall,Denise Horn,Danny Huylebroeck,Jakub Klapecki,Małgorzata Krajewska-Walasek,Alma Kuechler,Matthew A. Lines,Saskia M. Maas,Kay D. MacDermot,Shane McKee,Alex Magee,Stella A. de Man,Yves Moreau,Fanny Morice-Picard,Ewa Obersztyn,Jacek Pilch,Elizabeth C. Rosser,Nora Shannon,Irene Stolte-Dijkstra,Patrick Van Dijck,Catheline Vilain,Annick Vogels,Emma Wakeling,Dagmar Wieczorek,Louise C. Wilson,Orsetta Zuffardi,Antoine H. C. van Kampen,Koenraad Devriendt,Raoul C.M. Hennekam,Joris Vermeesch +49 more
TL;DR: The identification of SMARCA2 mutations in humans provides insight into the function of the Snf2 helicase family and alterations likely do not impair SWI/SNF complex assembly but may be associated with disrupted ATPase activity.
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Absence of an Orphan Mitochondrial Protein, C19orf12, Causes a Distinct Clinical Subtype of Neurodegeneration with Brain Iron Accumulation
Monika Hartig,Arcangela Iuso,Tobias B. Haack,Tomasz Kmieć,Elżbieta Jurkiewicz,Katharina Heim,Sigrun Roeber,Victoria Tarabin,Sabrina Dusi,Małgorzata Krajewska-Walasek,Sergiusz Jozwiak,Maja Hempel,Juliane Winkelmann,Matthias Elstner,Konrad Oexle,Thomas Klopstock,W. Mueller-Felber,Thomas Gasser,Claudia Trenkwalder,Valeria Tiranti,Hans A. Kretzschmar,Gerd Schmitz,Tim M. Strom,Thomas Meitinger,Holger Prokisch +24 more
TL;DR: The mitochondrial localization together with the immunohistopathological findings suggests a pathomechanistic overlap with common forms of neurodegenerative disorders.
Journal ArticleDOI
The mutational spectrum in Waardenburg syndrome
Mayada Tassabehji,Valerie Newton,Xue Zhong Liu,Xue Zhong Liu,Angela F. Brady,Dian Donnai,Małgorzata Krajewska-Walasek,Victoria Murday,Andrew Norman,Ewa Obersztyn,William Reardon,J. Rice,Richard C. Trembath,Peter Wieacker,Margo Whiteford,Robin M. Winter,Andrew P. Read +16 more
TL;DR: One hundred and thirty-four families or individuals with auditory-pigmentary syndromes such as Waardenburg syndrome (WS) or probable neurocristopathies were screened for mutations in the PAX3 and MITF genes as mentioned in this paper.