M
Matthias Peter
Researcher at ETH Zurich
Publications - 202
Citations - 24583
Matthias Peter is an academic researcher from ETH Zurich. The author has contributed to research in topics: Ubiquitin ligase & Cullin. The author has an hindex of 75, co-authored 192 publications receiving 21916 citations. Previous affiliations of Matthias Peter include ISREC & Swiss Institute of Bioinformatics.
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Journal ArticleDOI
The Clathrin Adaptor Gga2p Is a Phosphatidylinositol 4-phosphate Effector at the Golgi Exit
Lars Demmel,Maike Gravert,Ebru Ercan,Bianca Habermann,Thomas Müller-Reichert,Viktoria Kukhtina,Volker Haucke,Thorsten Baust,Marc Sohrmann,Yannis Kalaidzidis,Christian Klose,Michael Edmund Beck,Matthias Peter,Christiane Walch-Solimena +13 more
TL;DR: This analysis uncovered a PI(4)P-dependent recruitment of the clathrin adaptor Gga2p to the TGN during Golgi-to-endosome trafficking and provides an explanation for the T GN-specific membrane recruitment of GGA2p.
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An interaction network of the mammalian COP9 signalosome identifies Dda1 as a core subunit of multiple Cul4-based E3 ligases
Michael H. Olma,Marcia Roy,Thierry Le Bihan,Izabela Sumara,Sarah Maerki,Brett Larsen,Manfredo Quadroni,Matthias Peter,Mike Tyers,Lionel Pintard,Lionel Pintard +10 more
TL;DR: This analysis identifies new components of the CRL family of E3 ligases and elaborates new connections between the C RL and CSN complexes, including Dda1, which is characterized as a chromatin-associated core subunit of multiple CRL4 proteins.
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A Dual Protein-mRNA Localization Screen Reveals Compartmentalized Translation and Widespread Co-translational RNA Targeting.
Racha Chouaib,Adham Safieddine,Xavier Pichon,Arthur Imbert,Oh Sung Kwon,Aubin Samacoits,Abdel-Meneem Traboulsi,Marie-Cécile Robert,Nikolay Tsanov,Emeline Coleno,Ina Poser,Christophe Zimmer,Anthony A. Hyman,Hervé Le Hir,Kazem Zibara,Matthias Peter,Florian Mueller,Thomas Walter,Edouard Bertrand +18 more
TL;DR: A dual protein-mRNA localization screen using smFISH on human cell lines expressing GFP-tagged genes revealed a high degree of intercellular heterogeneity, and translation factories uniquely regulate nascent protein metabolism and create a fine granular compartmentalization of translation.
Journal ArticleDOI
Yeast split-ubiquitin-based cytosolic screening system to detect interactions between transcriptionally active proteins
Natalie Möckli,Anna Deplazes,Paul O. Hassa,Zhaolei Zhang,Matthias Peter,Michael O. Hottiger,Igor Stagljar,Daniel Auerbach +7 more
TL;DR: The cytosolic yeast two-hybrid system (cytoY2H) is presented, which is based on the split-ubiquitin technique and detects protein-protein interactions in the cytoplasm and applied to cDNA library screening and identified several new interaction partners of Uri1p, an uncharacterized yeast protein.
Journal ArticleDOI
Modular microfluidics enables kinetic insight from time-resolved cryo-EM
Märt-Erik Mäeots,Märt-Erik Mäeots,Byungjin Lee,Andrea Nans,Seung-Geun Jeong,Mohammad M. N. Esfahani,Shan Ding,Daniel J. Smith,Chang-Soo Lee,Sung Sik Lee,Matthias Peter,Radoslav I. Enchev,Radoslav I. Enchev +12 more
TL;DR: A time-resolved sample preparation method for cryo-EM called trEM is presented, which uses a microfluidic device to initiate the biochemical reaction by rapid mixing of the components and then spraying the sample onto a cryO-EM grid to snap-freeze it in a blot-free, automated manner within several milliseconds.