M
Mattia Forcato
Researcher at University of Modena and Reggio Emilia
Publications - 73
Citations - 9922
Mattia Forcato is an academic researcher from University of Modena and Reggio Emilia. The author has contributed to research in topics: Hippo signaling pathway & Medicine. The author has an hindex of 25, co-authored 64 publications receiving 7637 citations.
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Journal ArticleDOI
Role of YAP/TAZ in mechanotransduction
Sirio Dupont,Leonardo Morsut,Mariaceleste Aragona,Elena Enzo,Stefano Giulitti,Michelangelo Cordenonsi,Francesca Zanconato,Jimmy Le Digabel,Mattia Forcato,Silvio Bicciato,Nicola Elvassore,Stefano Piccolo +11 more
TL;DR: YAP/TAZ are identified as sensors and mediators of mechanical cues instructed by the cellular microenvironment and are functionally required for differentiation of mesenchymal stem cells induced by ECM stiffness and for survival of endothelial cells regulated by cell geometry.
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The Hippo Transducer TAZ Confers Cancer Stem Cell-Related Traits on Breast Cancer Cells
Michelangelo Cordenonsi,Francesca Zanconato,Luca Azzolin,Mattia Forcato,Antonio Rosato,Chiara Frasson,Masafumi Inui,Marco Montagner,Anna Parenti,Alessandro Poletti,Maria Grazia Daidone,Sirio Dupont,Giuseppe Basso,Silvio Bicciato,Stefano Piccolo +14 more
TL;DR: It is shown that the activity of TAZ, a transducer of the Hippo pathway, is required to sustain self-renewal and tumor-initiation capacities in breast CSCs and reveals a mechanistic basis of the control of Hippo kinases by cell polarity.
Journal ArticleDOI
Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth
Francesca Zanconato,Mattia Forcato,Giusy Battilana,Luca Azzolin,Erika Quaranta,Beatrice Bodega,Antonio Rosato,Silvio Bicciato,Michelangelo Cordenonsi,Stefano Piccolo +9 more
TL;DR: This work highlights a new layer of signalling integration, feeding on YAP/TAZ function at the chromatin level, which occurs almost exclusively from distal enhancers that contact target promoters through chromatin looping.
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IL-7 and IL-15 instruct the generation of human memory stem T cells from naïve precursors
Nicoletta Cieri,Barbara Camisa,Fabienne Cocchiarella,Mattia Forcato,Giacomo Oliveira,Elena Provasi,Attilio Bondanza,Claudio Bordignon,Jacopo Peccatori,Fabio Ciceri,Maria Teresa Lupo-Stanghellini,Fulvio Mavilio,Anna Mondino,Silvio Bicciato,Alessandra Recchia,Chiara Bonini +15 more
TL;DR: It is shown that it is possible to differentiate in vitro, expand, and gene modify in clinically compliant conditions CD8(+) T(SCM) lymphocytes starting from naive precursors, suggesting self-renewal capacity in a clinically relevant setting.
Journal ArticleDOI
Role of TAZ as Mediator of Wnt Signaling
Luca Azzolin,Francesca Zanconato,Silvia Bresolin,Mattia Forcato,Giuseppe Basso,Silvio Bicciato,Michelangelo Cordenonsi,Stefano Piccolo +7 more
TL;DR: It is reported that TAZ, a biologically potent transcriptional coactivator, serves as a downstream element of the Wnt/β-catenin cascade, and is functionally relevant to mediate Wnt biological effects.