Beatrice Bodega

TL;DR: For example, the authors mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body.

TL;DR: This work highlights a new layer of signalling integration, feeding on YAP/TAZ function at the chromatin level, which occurs almost exclusively from distal enhancers that contact target promoters through chromatin looping.

TL;DR: The data support a highly generalizable model in which enhancer transcription is the earliest event in successive waves of transcriptional change during cellular differentiation or activation.

TL;DR: Insight is provided into the biological function of repetitive sequences in regulating gene expression and how mutations of such elements can influence the progression of a human genetic disease.

TL;DR: A key role for lincRNA in T lymphocyte differentiation is demonstrated and a long-distance interaction between the genomic regions of the gene encoding linc-MAF-4 and MAF is identified, which suggested that l inc-MAf-4 regulated MAF transcription through the recruitment of chromatin modifiers.