Maura Sonego

TL;DR: It is suggested that blockage of VEGF through the use of an anti-VEGFA antibody may not be sufficient to improve survival in ovarian cancer patients unless VEGFB signaling is also blocked.

TL;DR: It is reported that the ubiquitin-specific protease 1 (USP1) mediates ovarian cancer cell resistance to platinum, by regulating the stability of Snail, which, in turn, promotes tumor dissemination.

TL;DR: It is demonstrated that this p27 function also influences morphology and motility of cells immersed in three-dimensional (3D)matrices, implicating that the balanced expression of p27 and stathmin represents a crucial determinant for cytoskeletal organization and cellular behavior in 3D contexts.

TL;DR: It is demonstrated here that surgery-induced inflammation promotes stem-like phenotypes and tumor-initiating abilities of breast cancer cells and the understanding of the crosstalk between breast tumor- initiating cells and their microenvironment may open the way to successful targeting of these cells in their initial stages of growth and be eventually curative.

TL;DR: The data suggest that CDK6 represents an actionable target that can be exploited to improve platinum efficacy in EOC patients, and can be immediately transferred to the clinic to improve the outcome of E OC patients.