M
Meena Datta
Researcher at National Centre for Disease Control
Publications - 9
Citations - 1266
Meena Datta is an academic researcher from National Centre for Disease Control. The author has contributed to research in topics: Monoclonal antibody & Vaccine efficacy. The author has an hindex of 8, co-authored 8 publications receiving 233 citations.
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Journal ArticleDOI
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Petra Mlcochova,Steven Kemp,Steven Kemp,Mahesh Shanker Dhar,Guido Papa,Bo Meng,Isabella Ferreira,Rawlings Datir,Dami A. Collier,Dami A. Collier,Anna Albecka,Sujeet Kumar Singh,Rajesh Pandey,Jonathan Brown,Jie Zhou,Niluka Goonawardane,Swapnil Mishra,Charles Whittaker,Thomas A. Mellan,Robin Marwal,Meena Datta,Shantanu Sengupta,Kalaiarasan Ponnusamy,V. S. Radhakrishnan,Adam Abdullahi,Oscar Charles,Partha Chattopadhyay,Priti Devi,Daniela Caputo,Thomas P. Peacock,Chand Wattal,Neeraj Goel,Ambrish Satwik,Raju Vaishya,Meenakshi Agarwal,Antranik Mavousian,Joo-Hyeon Lee,Jessica Bassi,Chiara Silacci-Fegni,Christian Saliba,Dora Pinto,Takashi Irie,Isao Yoshida,William L Hamilton,Kei Sato,Samir Bhatt,Samir Bhatt,Seth Flaxman,Leo C. James,Davide Corti,Luca Piccoli,Wendy S. Barclay,Partha Rakshit,Anurag Agrawal,Ravindra K. Gupta +54 more
TL;DR: The B.617.1.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike as discussed by the authors.
Journal ArticleDOI
Genomic characterization and epidemiology of an emerging SARS-CoV-2 variant in Delhi, India.
Mahesh Shanker Dhar,Robin Marwal,Radhakrishnan Vs,Kalaiarasan Ponnusamy,Bani Jolly,Rahul C. Bhoyar,Viren Sardana,Salwa Naushin,Mercy Rophina,Thomas A. Mellan,Swapnil Mishra,Charles Whittaker,Saman Fatihi,Meena Datta,Priyanka Singh,Uma Sharma,Rajat Ujjainiya,Nitin Bhatheja,Mohit Kumar Divakar,Manoj Kumar Singh,Mohamed Imran,Vigneshwar Senthivel,Ranjeet Maurya,Neha Jha,Priyanka Mehta,Vivekanand A,Pooja Sharma,Arvinden Vr,Urmila Chaudhary,Namita Soni,Lipi Thukral,Seth Flaxman,Samir Bhatt,Samir Bhatt,Rajesh Pandey,Debasis Dash,Mohammed Faruq,Hemlata Lall,Hema Gogia,Preeti Madan,Sanket Kulkarni,Himanshu Chauhan,Shantanu Sengupta,Sandhya Kabra,Ravindra K. Gupta,Sujeet Kumar Singh,Anurag Agrawal,Partha Rakshit,Vinay Nandicoori,Karthik Bharadwaj Tallapaka,Divya Tej Sowpati +50 more
TL;DR: In this paper, a Bayesian model explains the growth advantage of Delta through a combination of increased transmissibility and reduced sensitivity to immune responses generated against earlier variants (median estimates; ×1.5-fold, 20% reduction).
Posted ContentDOI
SARS-CoV-2 B.1.617.2 Delta variant emergence and vaccine breakthrough
Petra Mlcochova,Steven Kemp,Mahesh Shanker Dhar,Guido Papa,Bo Meng,Swapnil Mishra,Charles Whittaker,Thomas A. Mellan,Isabella Ferreira,Rawlings Datir,Dami A. Collier,Dami A. Collier,Sujeet Kumar Singh,Rajesh Pandey,Robin Marwal,Meena Datta,Shantanu Sengupta,Kalaiarasan Ponnusamy,V. S. Radhakrishnan,Adam Abdullahi,Niluka Goonawardne,Jonathan Brown,Oscar Charles,Partha Chattopadhyay,Priti Devi,Daniela Caputo,Thomas P. Peacock,Chand Wattal,Neeraj Goel,Raju Vaishya,Meenakshi Agarwal,o Hyeon Lee,Wendy S. Barcla,Samir Bhatt,Samir Bhatt,Seth Flaxman,Leo C. James,Partha Rakshit,Anurag Agrawal,Ravindra K. Gupta +39 more
TL;DR: Combined epidemiological and in vitro data indicate that the dominance of the Delta variant in India has been most likely driven by a combination of evasion of neutralising antibodies in previously infected individuals and increased virus infectivity.
Posted ContentDOI
Genomic characterization and Epidemiology of an emerging SARS-CoV-2 variant in Delhi, India
Mahesh Shanker Dhar,Robin Marwal,V. S. Radhakrishnan,Kalaiarasan Ponnusamy,Bani Jolly,Rahul C. Bhoyar,Viren Sardana,Salwa Naushin,Mercy Rophina,Thomas A. Mellan,Swapnil Mishra,Charles Whittaker,Saman Fatihi,Meena Datta,Priyanka Singh,Uma Sharma,Rajat Ujjainiya,Nitin Batheja,Mohit Kumar Divakar,Manoj Kumar Singh,Mohamed Imran,Vigneshwar Senthivel,Ranjeet Maurya,Neha Jha,Priyanka Mehta,A Vivekanand,Pooja Sharma,VR Arvinden,Urmila Chaudhary,Namita Soni,Lipi Thukral,Seth Flaxman,Samir Bhatt,Samir Bhatt,Rajesh Pandey,Debasis Dash,Mohammed Faruq,Hemlata Lall,Hema Gogia,Preeti Madan,Sanket Kulkarni,Himanshu Chauhan,Shantanu Sengupta,Sandhya Kabra,Ravindra K. Gupta,Sujeet Kumar Singh,Anurag Agrawal,Partha Rakshit +47 more
TL;DR: In this paper, the authors trace viral, host, and social factors contributing to the scale and exponent of the fourth wave of SARS-CoV2 pandemic, when compared to preceding waves, in an epidemiological context.
Posted ContentDOI
SARS-CoV-2 B.1.617.2 Delta variant replication, sensitivity to neutralising antibodies and vaccine breakthrough
Petra Mlcochova,Steven Kemp,Steven Kemp,Mahesh Shanker Dhar,Guido Papa,Bo Meng,Swapnil Mishra,Charles Whittaker,Thomas A. Mellan,Isabella Ferreira,Rawlings Datir,Dami A. Collier,Dami A. Collier,Anna Albecka,Sujeet Kumar Singh,Rajesh Pandey,Jonathan Brown,Jie Zhou,Niluka Goonawardne,Robin Marwal,Meena Datta,Shantanu Sengupta,Kalaiarasan Ponnusamy,V. S. Radhakrishnan,Adam Abdullahi,Oscar Charles,Partha Chattopadhyay,Priti Devi,Daniela Caputo,Thomas P. Peacock,Chand Wattal,Neeraj Goel,Ambrish Satwik,Raju Vaishya,Meenakshi Agarwal,Antranik Mavousian,Joo-Hyeon Lee,Jessica Bassi,Chiara Silacci-Fegni,Christian Saliba,Dora Pinto,Takashi Irie,Isao Yoshida,William L Hamilton,Kei Sato,Leo C. James,Davide Corti,Luca Piccoli,Samir Bhatt,Samir Bhatt,Seth Flaxman,Wendy S. Barclay,Partha Rakshit,Anurag Agrawal,Ravindra K. Gupta +54 more
TL;DR: The SARS-CoV-2 B.1.617.2 spike pseudotyped viruses exhibited compromised sensitivity to monoclonal antibodies against the receptor binding domain (RBD) and N-terminal domain (NTD).