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Isao Yoshida
Publications - 9
Citations - 1128
Isao Yoshida is an academic researcher. The author has contributed to research in topics: Monoclonal antibody & Vaccine efficacy. The author has an hindex of 6, co-authored 9 publications receiving 216 citations.
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Journal ArticleDOI
SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion.
Petra Mlcochova,Steven Kemp,Steven Kemp,Mahesh Shanker Dhar,Guido Papa,Bo Meng,Isabella Ferreira,Rawlings Datir,Dami A. Collier,Dami A. Collier,Anna Albecka,Sujeet Kumar Singh,Rajesh Pandey,Jonathan Brown,Jie Zhou,Niluka Goonawardane,Swapnil Mishra,Charles Whittaker,Thomas A. Mellan,Robin Marwal,Meena Datta,Shantanu Sengupta,Kalaiarasan Ponnusamy,V. S. Radhakrishnan,Adam Abdullahi,Oscar Charles,Partha Chattopadhyay,Priti Devi,Daniela Caputo,Thomas P. Peacock,Chand Wattal,Neeraj Goel,Ambrish Satwik,Raju Vaishya,Meenakshi Agarwal,Antranik Mavousian,Joo-Hyeon Lee,Jessica Bassi,Chiara Silacci-Fegni,Christian Saliba,Dora Pinto,Takashi Irie,Isao Yoshida,William L Hamilton,Kei Sato,Samir Bhatt,Samir Bhatt,Seth Flaxman,Leo C. James,Davide Corti,Luca Piccoli,Wendy S. Barclay,Partha Rakshit,Anurag Agrawal,Ravindra K. Gupta +54 more
TL;DR: The B.617.1.2 spike protein was able to mediate highly efficient syncytium formation that was less sensitive to inhibition by neutralizing antibody, compared with that of wild-type spike as discussed by the authors.
Posted ContentDOI
SARS-CoV-2 spike P681R mutation, a hallmark of the Delta variant, enhances viral fusogenicity and pathogenicity
Akatsuki Saito,Takashi Irie,Rigel Suzuki,Tadashi Maemura,Tadashi Maemura,Hesham Nasser,Hesham Nasser,Keiya Uriu,Yusuke Kosugi,Kotaro Shirakawa,Kenji Sadamasu,Izumi Kimura,Jumpei Ito,Jiaqi Wu,Kiyoko Iwatsuki-Horimoto,Mutsumi Ito,Seiya Yamayoshi,Seiya Yamayoshi,Seiya Ozono,Erika P Butlertanaka,Yuri L Tanaka,Ryo Shimizu,Kenta Shimizu,Kumiko Yoshimatsu,Ryoko Kawabata,Takemasa Sakaguchi,Kenzo Tokunaga,Isao Yoshida,Hiroyuki Asakura,Mami Nagashima,Yasuhiro Kazuma,Ryosuke Nomura,Yoshihito Horisawa,Kazuhisa Yoshimura,Akifumi Takaori-Kondo,Masaki Imai,Masaki Imai,So Nakagawa,Terumasa Ikeda,Takasuke Fukuhara,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Yoshihiro Kawaoka,Kei Sato +43 more
TL;DR: In this paper, the authors show that the B.1.617.2/Delta variant is highly fusogenic, and notably more pathogenic than prototypic SARS-CoV-2 in infected hamsters.
Posted ContentDOI
SARS-CoV-2 spike P681R mutation enhances and accelerates viral fusion
Akatsuki Saito,Rigel Suzuki,Rigel Suzuki,Tadashi Maemura,Hesham Nasser,Hesham Nasser,Keiya Uriu,Yusuke Kosugi,Kotaro Shirakawa,Kenji Sadamasu,Izumi Kimura,Jumpei Ito,Jiaqi Wu,Kiyoko Iwatsuki-Horimoto,Mutsumi Ito,Seiya Yamayoshi,Seiya Ozono,Erika P Butlertanaka,Yuri L Tanaka,Ryo Shimizu,Kenta Shimizu,Kumiko Yoshimatsu,Ryoko Kawabata,Takemasa Sakaguchi,Kenzo Tokunaga,Isao Yoshida,Hiroyuki Asakura,Mami Nagashima,Yasuhiro Kazuma,Ryosuke Nomura,Yasuhito Horisawa,Kazuhisa Yoshimura,Akifumi Takaori-Kondo,Masaki Imai,So Nakagawa,Terumasa Ikeda,Takasuke Fukuhara,Yoshihiro Kawaoka,Kei Sato +38 more
TL;DR: In this paper, the authors show that the P681R mutation facilitates the furin-mediated spike cleavage and enhances and accelerates cell-cell fusion in the B.1.617 lineage.
Posted ContentDOI
SARS-CoV-2 B.1.617 emergence and sensitivity to vaccine-elicited antibodies
Petra Mlcochova,Steven Kemp,Mahesh Shanker Dhar,Guido Papa,Bo Meng,Swapnil Mishra,C. R. Whittaker,Mellan Ta,Isabella Ferreira,Rawlings Datir,Dami A. Collier,Sujeet Kumar Singh,Rajesh Pandey,Kalaiarasan Ponnusamy,V. S. Radhakrishnan,Shantanu Sengupta,Jonathan Brown,Robin Marwal,Niluka Goonawardne,Adam Abdullahi,Priti Devi,Chand Wattal,Daniela Caputo,Thomas P. Peacock,Neeraj Goel,Raju Vaishya,Oscar Charles,Partha Chattopadhyay,Meenakshi Agarwal,Ambrish Satwik,Antranik Mavousian,Jie Zhou,Joo-Hyeon Lee,Jessica Bassi,Chiara Silacci-Fegni,Christian Saliba,Dora Pinto,Takashi Irie,Isao Yoshida,William L. Hamilton,Kei Sato,Leo C. James,Davide Corti,Luca Piccoli,Samir Bhatt,Seth Flaxman,Wendy Barlcay,Partha Rakshit,Anurag Agrawal,Ravindra K. Gupta +49 more
TL;DR: In this paper, the authors demonstrate that B.1.2 is approximately 6-fold less sensitive to neutralising antibodies in sera from recovered individuals, and approximately 8-fold more sensitive to vaccine-elicited antibodies as compared to Wuhan-1 bearing D614G.
Posted ContentDOI
SARS-CoV-2 B.1.617.2 Delta variant replication, sensitivity to neutralising antibodies and vaccine breakthrough
Petra Mlcochova,Steven Kemp,Steven Kemp,Mahesh Shanker Dhar,Guido Papa,Bo Meng,Swapnil Mishra,Charles Whittaker,Thomas A. Mellan,Isabella Ferreira,Rawlings Datir,Dami A. Collier,Dami A. Collier,Anna Albecka,Sujeet Kumar Singh,Rajesh Pandey,Jonathan Brown,Jie Zhou,Niluka Goonawardne,Robin Marwal,Meena Datta,Shantanu Sengupta,Kalaiarasan Ponnusamy,V. S. Radhakrishnan,Adam Abdullahi,Oscar Charles,Partha Chattopadhyay,Priti Devi,Daniela Caputo,Thomas P. Peacock,Chand Wattal,Neeraj Goel,Ambrish Satwik,Raju Vaishya,Meenakshi Agarwal,Antranik Mavousian,Joo-Hyeon Lee,Jessica Bassi,Chiara Silacci-Fegni,Christian Saliba,Dora Pinto,Takashi Irie,Isao Yoshida,William L Hamilton,Kei Sato,Leo C. James,Davide Corti,Luca Piccoli,Samir Bhatt,Samir Bhatt,Seth Flaxman,Wendy S. Barclay,Partha Rakshit,Anurag Agrawal,Ravindra K. Gupta +54 more
TL;DR: The SARS-CoV-2 B.1.617.2 spike pseudotyped viruses exhibited compromised sensitivity to monoclonal antibodies against the receptor binding domain (RBD) and N-terminal domain (NTD).