M
Megumi Hatori
Researcher at Salk Institute for Biological Studies
Publications - 27
Citations - 4291
Megumi Hatori is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Circadian rhythm & Circadian clock. The author has an hindex of 17, co-authored 26 publications receiving 3497 citations. Previous affiliations of Megumi Hatori include National Presto Industries & Keio University.
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Journal ArticleDOI
Time-Restricted Feeding without Reducing Caloric Intake Prevents Metabolic Diseases in Mice Fed a High-Fat Diet
Megumi Hatori,Christopher Vollmers,Amir Zarrinpar,Amir Zarrinpar,Luciano DiTacchio,Eric A. Bushong,Shubhroz Gill,Mathias Leblanc,Amandine Chaix,Matthew S. Joens,James A. J. Fitzpatrick,Mark H. Ellisman,Satchidananda Panda +12 more
TL;DR: Mice under tRF consume equivalent calories from HFD as those with ad lib access yet are protected against obesity, hyperinsulinemia, hepatic steatosis, and inflammation and have improved motor coordination.
Journal ArticleDOI
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
Han Cho,Xuan Zhao,Megumi Hatori,Ruth T. Yu,Grant D. Barish,Michael T. Lam,Ling Wa Chong,Luciano DiTacchio,Annette R. Atkins,Christopher K. Glass,Christopher Liddle,Johan Auwerx,Michael Downes,Satchidananda Panda,Ronald M. Evans +14 more
TL;DR: The cistromic analysis reveals a more profound connection between BMAL1 and the REV-ERB-α and REB-β genomic regulatory circuits than was previously suspected and indicates a more integral mechanism for the coordination of circadian rhythm and metabolism.
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Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines.
Rajesh Narasimamurthy,Megumi Hatori,Surendra Kumar Nayak,Fei Liu,Satchidananda Panda,Inder M. Verma +5 more
TL;DR: It is shown that absence of the core clock component protein cryptochrome (CRY) leads to constitutive elevation of proinflammatory cytokines in a cell-autonomous manner, and that CRY1 binds to adenylyl cyclase and limits cAMP production.
Journal ArticleDOI
Inducible ablation of melanopsin-expressing retinal ganglion cells reveals their central role in non-image forming visual responses.
Megumi Hatori,Hiep D. Le,Christopher Vollmers,Sheena Racheal Keding,Nobushige Tanaka,Christian Schmedt,Timothy Jegla,Satchidananda Panda +7 more
TL;DR: The results point to the mRGCs as the site of functional integration of the rod/cone and melanopsin phototransduction pathways and as the primary anatomical site for the divergence of image-forming and non-image forming photoresponses in mammals.
Journal ArticleDOI
Melanopsin Contributions to Irradiance Coding in the Thalamo-Cortical Visual System
Timothy M. Brown,Carlos Gias,Megumi Hatori,Sheena Racheal Keding,Ma'ayan Semo,Peter J. Coffey,John Gigg,Hugh D. Piggins,Satchidananda Panda,Robert J. Lucas +9 more
TL;DR: Neurophysiological and anatomical studies identify melanopsin expressing retinal ganglion cells (mRGCs) as a major source of information in the mouse visual system.