Timothy M. Brown

TL;DR: A new light-measurement strategy taking account of the complex photoreceptive inputs to these non-visual responses is proposed for use by researchers, and simple suggestions for artificial/architectural lighting are provided for regulatory authorities, lighting manufacturers, designers, and engineers.

TL;DR: These whole-animal and biochemical studies explain how tau, as a gain-of-function mutation, acts at a specific circadian phase to promote degradation of PERIOD proteins and thereby accelerate the mammalian clockwork in brain and periphery.

TL;DR: Neurophysiological and anatomical studies identify melanopsin expressing retinal ganglion cells (mRGCs) as a major source of information in the mouse visual system.

TL;DR: It is shown that pupillomotor and circadian responses of mice relying solely on melanopsin for their photosensitivity can indeed be accurately predicted using the 480-nm nomogram, and that measuring light in these terms predicts the melanopsIn response to light of divergent spectral composition much more reliably than other methods for quantifying irradiance or illuminance currently in widespread use.

TL;DR: This work used parallel behavioral and electrophysiological experiments to first show that melanopsin contributes to brightness discrimination in both retinally degenerate and fully sighted mice, and to provide evidence for a similar role in healthy human subjects.