L
Leslie N. Aldrich
Researcher at Harvard University
Publications - 14
Citations - 519
Leslie N. Aldrich is an academic researcher from Harvard University. The author has contributed to research in topics: Autophagy & Cancer. The author has an hindex of 9, co-authored 11 publications receiving 436 citations. Previous affiliations of Leslie N. Aldrich include Vanderbilt University Medical Center & Broad Institute.
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Journal ArticleDOI
Atg16l1 is Required for Autophagy in Intestinal Epithelial Cells and Protection of Mice From Salmonella Infection
Kara L. Conway,Petric Kuballa,Joo Hye Song,Khushbu Patel,Adam B. Castoreno,Ömer H. Yilmaz,Humberto Jijon,Mei Zhang,Leslie N. Aldrich,Eduardo J. Villablanca,Joanna M. Peloquin,Gautam Goel,In-Ah Lee,Emiko Mizoguchi,Hai Ning Shi,Atul K. Bhan,Stanley Y. Shaw,Stuart L. Schreiber,Herbert W. Virgin,Alykhan F. Shamji,Thaddeus S. Stappenbeck,Hans Christian Reinecker,Ramnik J. Xavier +22 more
TL;DR: Atg16l1 regulates autophagy in intestinal epithelial cells and is required for bacterial clearance, and also is required to prevent systemic infection of mice with enteric bacteria.
Journal ArticleDOI
Selective modulation of autophagy, innate immunity, and adaptive immunity by small molecules.
Stanley Y. Shaw,Khoa D. Tran,Adam B. Castoreno,Joanna M. Peloquin,Kara G. Lassen,Bernard Khor,Leslie N. Aldrich,Leslie N. Aldrich,Pauline H. Tan,Daniel B. Graham,Petric Kuballa,Gautam Goel,Mark J. Daly,Mark J. Daly,Alykhan F. Shamji,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,Ramnik J. Xavier,Ramnik J. Xavier +19 more
TL;DR: In macrophages from mice bearing a conditional deletion of the essential autophagy gene Atg16L1, the small molecules inhibit IL-1β production to varying degrees suggesting that individual compounds may possess both autophophagy-dependent and autophagic-independent activity on immune pathways.
Journal ArticleDOI
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics
Szu Yu Kuo,Szu Yu Kuo,Adam B. Castoreno,Leslie N. Aldrich,Leslie N. Aldrich,Kara G. Lassen,Kara G. Lassen,Gautam Goel,Gautam Goel,Vlado Dančík,Petric Kuballa,Petric Kuballa,Isabel J. Latorre,Kara L. Conway,Kara L. Conway,Sovan Sarkar,Sovan Sarkar,Dorothea Maetzel,Rudolf Jaenisch,Rudolf Jaenisch,Paul A. Clemons,Stuart L. Schreiber,Stuart L. Schreiber,Stuart L. Schreiber,Alykhan F. Shamji,Ramnik J. Xavier,Ramnik J. Xavier +26 more
TL;DR: BRD5631 affects several cellular disease phenotypes previously linked to autophagy, including protein aggregation, cell survival, bacterial replication, and inflammatory cytokine production, and can serve as a valuable tool for studying the role of Autophagy in the context of cellular homeostasis and disease.
Journal ArticleDOI
Discovery of a Small-Molecule Probe for V-ATPase Function
Leslie N. Aldrich,Szu Yu Kuo,Adam B. Castoreno,Gautam Goel,Petric Kuballa,Matthew G. Rees,Brinton Seashore-Ludlow,Jaime H. Cheah,Isabel J. Latorre,Stuart L. Schreiber,Alykhan F. Shamji,Ramnik J. Xavier +11 more
TL;DR: The discovery of a novel, small-molecule modulator of lysosomal acidification derived from diversity-oriented synthesis through high-content screening is reported.
Journal ArticleDOI
Evaluation of the biosynthetic proposal for the synthesis of marineosins A and B.
TL;DR: The first synthetic efforts toward marineosins A and B, novel spiroaminals from a Streptomyces actinomycete, are described by evaluation of the proposed biosynthesis, where the proposed biomimetic inverse-electron-demand hetero-Diels-Alder reaction failed to deliver the marineosin core.