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Chien-wen Su
Researcher at Harvard University
Publications - 21
Citations - 837
Chien-wen Su is an academic researcher from Harvard University. The author has contributed to research in topics: Immune system & Heligmosomoides polygyrus. The author has an hindex of 8, co-authored 17 publications receiving 499 citations.
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Journal ArticleDOI
T Helper Cell Cytokines Modulate Intestinal Stem Cell Renewal and Differentiation.
Moshe Biton,Moshe Biton,Adam L. Haber,Noga Rogel,Grace Burgin,Semir Beyaz,Semir Beyaz,Semir Beyaz,Alexandra Schnell,Orr Ashenberg,Chien-wen Su,Christopher Smillie,Karthik Shekhar,Zuojia Chen,Chuan Wu,Jose Ordovas-Montanes,David Alvarez,Rebecca H. Herbst,Rebecca H. Herbst,Mei Zhang,Itay Tirosh,Itay Tirosh,Danielle Dionne,Lan T. Nguyen,Michael E. Xifaras,Alex K. Shalek,Ulrich H. von Andrian,Daniel B. Graham,Orit Rozenblatt-Rosen,Hai Ning Shi,Vijay K. Kuchroo,Vijay K. Kuchroo,Ömer H. Yilmaz,Ömer H. Yilmaz,Ömer H. Yilmaz,Aviv Regev,Aviv Regev,Ramnik J. Xavier +37 more
TL;DR: It is shown that MHCII+ Lgr5+ ISCs are non-conventional antigen-presenting cells in co-cultures with CD4+ T helper (Th) cells, which orchestrate tissue-wide responses to external signals.
Journal ArticleDOI
Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses
Xu Heping,Xu Heping,Jiarui Ding,Caroline B. M. Porter,Antonia Wallrapp,Marcin Tabaka,Sai Ma,Shujie Fu,Xuanxuan Guo,Samantha J. Riesenfeld,Chien-wen Su,Danielle Dionne,Lan T. Nguyen,Ariel Lefkovith,Orr Ashenberg,Patrick R. Burkett,Hai Ning Shi,Orit Rozenblatt-Rosen,Daniel B. Graham,Vijay K. Kuchroo,Vijay K. Kuchroo,Aviv Regev,Aviv Regev,Ramnik J. Xavier +23 more
TL;DR: This work highlights a model where α-CGRP-mediated neuronal signaling is critical for suppressing ILC2 expansion and maintaining homeostasis of the type 2 immune machinery.
Journal ArticleDOI
Helminth-induced alterations of the gut microbiota exacerbate bacterial colitis.
Chien-wen Su,Libo Su,Libo Su,Yali Li,Yali Li,Shao Rong Long,Jeffrey Chang,W Zhang,W Zhang,W A Walker,Ramnik J. Xavier,Bobby J. Cherayil,Hai Ning Shi +12 more
TL;DR: In this article, the authors showed that infection with the intestinal helminth parasite Heligmosomoides polygyrus exacerbates colitis caused by the bacterial enteropathogen Citrobacter rodentium.
Journal ArticleDOI
Helminth infection protects against high fat diet-induced obesity via induction of alternatively activated macrophages
Chien-wen Su,Chih-Yu Chen,Yali Li,Shao Rong Long,William Massey,Deepak Kumar,W. Allan Walker,Hai Ning Shi +7 more
TL;DR: Evidence is provided that the helminth-dependent protection against obesity involves the induction of M2 macrophages, as demonstrated in mice infected with the intestinal nematode parasite Heligmosomoides polygyrus.
Journal ArticleDOI
Coinfection with an Intestinal Helminth Impairs Host Innate Immunity against Salmonella enterica Serovar Typhimurium and Exacerbates Intestinal Inflammation in Mice
Libo Su,Libo Su,Chien-wen Su,Yujuan Qi,Gui-Lian Yang,Mei Zhang,Bobby J. Cherayil,Xichen Zhang,Hai Ning Shi +8 more
TL;DR: The results suggest that impaired neutrophil recruitment is an important contributor to the enhanced severity of Salmonella enterocolitis associated with helminth coinfection.